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Table 2 Changes of the serum levels of biomarkers in patients with sepsis-associated liver dysfunction initially infected by bacteria after treatment with or without continuous hemofiltration

From: Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children

Variables

Conventional group (n = 11)

Continuous hemofiltration group (n = 16)

T0

T72

P

T0

T72

P

ALT

548.20 ± 264.14

427.55 ± 241.37

0.277

570.00 ± 229.97

418.81 ± 205.74

0.059

AST

1011.11 ± 639.04

721.09 ± 330.22

0.196

1007.81 ± 833.87

611.81 ± 597.51

0.133

γ-GT

185.45 ± 152.1

160.91 ± 126.62

0.685

165.06 ± 83.58

168.15 ± 71.53

0.911

TBIL

176.74 ± 81.01

132.87 ± 75.72

0.204

185.52 ± 142.48

62.59 ± 59.60

0.003*

DBIL

133.34 ± 62.75

99.07 ± 43.66

0.153

141.73 ± 103.96

49.05 ± 25.65

0.002*

TBA

97.31 ± 33.32

93.95 ± 49.00

0.853

104.73 ± 24.57

78.40 ± 17.54

0.002*

ALP

183.27 ± 20.18

175.00 ± 42.37

0.565

159.56 ± 36.35

137.25 ± 59.23

0.209

PT

24.60 ± 22.70

13.53 ± 3.29

0.125

26.78 ± 17.01

14.29 ± 5.89

0.009*

APTT

61.56 ± 19.75

53.25 ± 18.04

0.315

63.15 ± 33.76

51.38 ± 22.75

0.256

INR

1.61 ± 0.82

1.48 ± 0.30

0.631

2.20 ± 1.69

1.43 ± 0.36

0.084

Fib

1.57 ± 0.92

2.05 ± 0.70

0.180

1.79 ± 0.64

2.14 ± 0.49

0.097

Lac

5.26 ± 4.48

2.07 ± 1.77

0.040

4.45 ± 3.17

2.33 ± 2.15

0.034*

Ammonia

169.44 ± 60.73

109.66 ± 33.35

0.010*

153.12 ± 79.66

67.44 ± 26.42

< 0.001*

TNF-α

107.01 ± 41.78

98.23 ± 22.95

0.548

107.00 ± 31.35

76.03 ± 21.84

0.003*

IL-6

86.75 ± 29.14

69.10 ± 20.00

0.113

81.64 ± 23.85

52.66 ± 15.92

< 0.001*

  1. ALT alanine transaminase, U/L, AST aspartate aminotransferase, U/L, γ-GT γ-glutamyltransferase, U/L, TBIL total bilirubin, μmol/L, DBIL direct bilirubin, μmol/L, TBA total bile acid, μmol/L, ALP alkaline phosphatase, U/L, PT prothrombin time, s, APTT activated partial thromboplastin time, s, INR international normalized ratio, Fib ferritin, g/L, Lac lactate, mmol/L; Ammonia, μmol/L, TNF-α tumor necrosis factor α, pg/mL, IL-6 interleukin 6, pg/mL, T0: baseline before treatment, T72: 72 h after treatment
  2. * indicates P < 0.05 compared with T0