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Table 2 Changes of the serum levels of biomarkers in patients with sepsis-associated liver dysfunction initially infected by bacteria after treatment with or without continuous hemofiltration

From: Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children

Variables Conventional group (n = 11) Continuous hemofiltration group (n = 16)
T0 T72 P T0 T72 P
ALT 548.20 ± 264.14 427.55 ± 241.37 0.277 570.00 ± 229.97 418.81 ± 205.74 0.059
AST 1011.11 ± 639.04 721.09 ± 330.22 0.196 1007.81 ± 833.87 611.81 ± 597.51 0.133
γ-GT 185.45 ± 152.1 160.91 ± 126.62 0.685 165.06 ± 83.58 168.15 ± 71.53 0.911
TBIL 176.74 ± 81.01 132.87 ± 75.72 0.204 185.52 ± 142.48 62.59 ± 59.60 0.003*
DBIL 133.34 ± 62.75 99.07 ± 43.66 0.153 141.73 ± 103.96 49.05 ± 25.65 0.002*
TBA 97.31 ± 33.32 93.95 ± 49.00 0.853 104.73 ± 24.57 78.40 ± 17.54 0.002*
ALP 183.27 ± 20.18 175.00 ± 42.37 0.565 159.56 ± 36.35 137.25 ± 59.23 0.209
PT 24.60 ± 22.70 13.53 ± 3.29 0.125 26.78 ± 17.01 14.29 ± 5.89 0.009*
APTT 61.56 ± 19.75 53.25 ± 18.04 0.315 63.15 ± 33.76 51.38 ± 22.75 0.256
INR 1.61 ± 0.82 1.48 ± 0.30 0.631 2.20 ± 1.69 1.43 ± 0.36 0.084
Fib 1.57 ± 0.92 2.05 ± 0.70 0.180 1.79 ± 0.64 2.14 ± 0.49 0.097
Lac 5.26 ± 4.48 2.07 ± 1.77 0.040 4.45 ± 3.17 2.33 ± 2.15 0.034*
Ammonia 169.44 ± 60.73 109.66 ± 33.35 0.010* 153.12 ± 79.66 67.44 ± 26.42 < 0.001*
TNF-α 107.01 ± 41.78 98.23 ± 22.95 0.548 107.00 ± 31.35 76.03 ± 21.84 0.003*
IL-6 86.75 ± 29.14 69.10 ± 20.00 0.113 81.64 ± 23.85 52.66 ± 15.92 < 0.001*
  1. ALT alanine transaminase, U/L, AST aspartate aminotransferase, U/L, γ-GT γ-glutamyltransferase, U/L, TBIL total bilirubin, μmol/L, DBIL direct bilirubin, μmol/L, TBA total bile acid, μmol/L, ALP alkaline phosphatase, U/L, PT prothrombin time, s, APTT activated partial thromboplastin time, s, INR international normalized ratio, Fib ferritin, g/L, Lac lactate, mmol/L; Ammonia, μmol/L, TNF-α tumor necrosis factor α, pg/mL, IL-6 interleukin 6, pg/mL, T0: baseline before treatment, T72: 72 h after treatment
  2. * indicates P < 0.05 compared with T0