Table 1 Demographic and clinical characteristics of patients with sepsis complicated by liver dysfunction enrolled in this study
Demographic and Clinical Characteristics | Conventional group (n = 11) | Continuous hemofiltration group (n = 16) | P |
|---|---|---|---|
Age, month, median (range) | 12 (2–192) | 54 (3–144) | 0.239 |
Male, n (%) | 6 (54.5%) | 7 (43.7%) | 0.581 |
Stay in PICU, day, median (range) | 14 (4–36) | 9 (4–23) | 0.022* |
Body temperature, oC | 38.3 (36.0–40.0) | 39 (38.0–41.0) | 0.080 |
Hepatomegaly, n (%) | 6 (54.5%) | 10 (62.5%) | 0.679 |
Hypoproteinemia, n (%) | 9 (81.8%) | 13 (81.3%) | 0.970 |
Pediatric Risk of Mortality III (PRISM III), median (range) | 13(10–18) | 14 (10–20) | 0.427 |
Co-organ dysfunction | |||
ARDS, n (%) | 5 (45.4%) | 8 (50%) | 0.816 |
Kidney injury, n (%) | 4 (36.4%) | 7 (43.7%) | 0.701 |
Encephalopathy, n (%) | 2 (18.2%) | 8 (50%) | 0.202 |
Shock, n (%) | 5 (45.4%) | 8 (50.0%) | 0.816 |
Infection origin | |||
Respiratory system, n (%) | 5 (45.4%) | 6 (37.5%) | 0.679 |
Digestive system, n (%) | 3 (27.3%) | 4 (25.0%) | 0.895 |
Urinary system, n (%) | 1 (9.1%) | 2 (12.5%) | 0.780 |
Central nervous system, n (%) | 2 (18.2%) | 4 (25.0%) | 0.673 |
Pathogens | |||
Escherichia coli, n | 4 (9.1%) | 6 (37.65%) | 0.952 |
Pseudomonas aeruginosa, n | 3 (27.3%) | 3 (18.8%) | 0.603 |
Klebsiellapneumoniae, n | 0 (0%) | 1 (6.3%) | 1.000 |
Streptococcus pneumoniae, n | 3 (27.3%) | 4 (25.0%) | 0.895 |
Staphylococcus aureus, n | 1 (9.1%) | 2 (12.5%) | 0.780 |
Infection markers | |||
WBC | 11.85 ± 6.90 | 12.10 ± 8.07 | 0.933 |
PCT | 5.21 ± 4.29 | 6.39 ± 4.28 | 0.489 |
CRP | 98.09 ± 55.29 | 98.25 ± 53.47 | 0.994 |
Liver function | |||
PT | 24.60 ± 22.70 | 26.78 ± 17.01 | 0.778 |
ALT | 548.20 ± 264.14 | 570.00 ± 229.97 | 0.822 |
TBIL | 176.74 ± 81.01 | 185.52 ± 142.48 | 0.855 |
DBIL | 133.34 ± 62.75 | 141.73 ± 103.95 | 0.813 |
28-day mortality, n (%) | 8 (72.7%) | 5 (31.3%) | 0.034* |