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Table 1 Demographic and clinical characteristics of patients with sepsis complicated by liver dysfunction enrolled in this study

From: Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children

Demographic and Clinical Characteristics Conventional group (n = 11) Continuous hemofiltration group (n = 16) P
Age, month, median (range) 12 (2–192) 54 (3–144) 0.239
Male, n (%) 6 (54.5%) 7 (43.7%) 0.581
Stay in PICU, day, median (range) 14 (4–36) 9 (4–23) 0.022*
Body temperature, oC 38.3 (36.0–40.0) 39 (38.0–41.0) 0.080
Hepatomegaly, n (%) 6 (54.5%) 10 (62.5%) 0.679
Hypoproteinemia, n (%) 9 (81.8%) 13 (81.3%) 0.970
Pediatric Risk of Mortality III
(PRISM III), median (range)
13(10–18) 14 (10–20) 0.427
Co-organ dysfunction
 ARDS, n (%) 5 (45.4%) 8 (50%) 0.816
 Kidney injury, n (%) 4 (36.4%) 7 (43.7%) 0.701
 Encephalopathy, n (%) 2 (18.2%) 8 (50%) 0.202
 Shock, n (%) 5 (45.4%) 8 (50.0%) 0.816
Infection origin
 Respiratory system, n (%) 5 (45.4%) 6 (37.5%) 0.679
 Digestive system, n (%) 3 (27.3%) 4 (25.0%) 0.895
 Urinary system, n (%) 1 (9.1%) 2 (12.5%) 0.780
 Central nervous system, n (%) 2 (18.2%) 4 (25.0%) 0.673
Pathogens
Escherichia coli, n 4 (9.1%) 6 (37.65%) 0.952
Pseudomonas aeruginosa, n 3 (27.3%) 3 (18.8%) 0.603
Klebsiellapneumoniae, n 0 (0%) 1 (6.3%) 1.000
Streptococcus pneumoniae, n 3 (27.3%) 4 (25.0%) 0.895
Staphylococcus aureus, n 1 (9.1%) 2 (12.5%) 0.780
Infection markers
 WBC 11.85 ± 6.90 12.10 ± 8.07 0.933
 PCT 5.21 ± 4.29 6.39 ± 4.28 0.489
 CRP 98.09 ± 55.29 98.25 ± 53.47 0.994
Liver function
 PT 24.60 ± 22.70 26.78 ± 17.01 0.778
 ALT 548.20 ± 264.14 570.00 ± 229.97 0.822
 TBIL 176.74 ± 81.01 185.52 ± 142.48 0.855
 DBIL 133.34 ± 62.75 141.73 ± 103.95 0.813
28-day mortality, n (%) 8 (72.7%) 5 (31.3%) 0.034*
  1. ARDS acute respiratory distress syndrome, MODS multiple organ dysfunction syndrome, WBC white blood cell, ×109/L, PCT procalcitonin, ng/mL, CRP C-reactive protein, mg/L, PT prothrombin time, s, ALT alanine transaminase, U/L, TBIL total bilirubin, μmol/L, DBIL direct bilirubin, μmol/L
  2. * indicates P < 0.05 compared with conventional group