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Table 2 Correlation between mtDNA and different disease, PCIS score, organs damage and fatality

From: Use of plasma mitochondrial DNA levels for determining disease severity and prognosis in pediatric sepsis: a case control study

 

mt-DNA

PCT

Lactate

Value (pg/ml)

Text Value

p

Value (ng/ml)

Text Value

p

Value (mmol/l)

Text Value

p

Disease

Normal

30

278.14 (185.14–351.56)

 

0.01a**

      

General sepsis

70

667.35 (412.58–893.71)

  

1.05 (0.17~ 3.41)

−6.58

0.000d***

1.1 ± 2.15

− 3.887

0.000e***

Severe sepsis

53

1502.77 (1166.01–2221.88)

110.20

0.000b***

26.8 (4.51~ 174.33)

  

2.7 ± 3.45

  

Non-sepsis infection

30

433.54 (243.41–938.08)

 

0.05c*

      

PCIS score

>90

34

647.20 (410.73~ 989.46)

24.33

0.000***

1.23 (0.17–6.35)

23.57

0.000***

1.49 ± 1.19

9.19

0.000***

81~ 90

47

888.47 (474.645~ 1379.51)

  

2.51 (0.21–16.39)

  

1.88 ± 1.71

  

71~ 80

36

1184.82 (905.27~ 1997.40)

  

7.64 (1.36–137.51)

  

4.53 ± 3.97

  

≤70

7

1997.40 (1159.18~ 2601.67)

  

171.36 (12.97–200.00)

  

3.57 ± 4.54

  

amount of organs damage

0

37

474.65 (346.14–876.79)

63.30

0.000***

0.35 (0.09–3.13)

38.40

0.000***

1.71 ± 1.52

7.081

0.001

1

31

821.83 (522.42–1035.84)

  

2.51 (0.41–4.41)

  

1.84 ± 2.62

  

≧2

55

1454.78 (1141.13–2195.98)

  

12.97 (3.95–151.74)

  

3.72 ± 3.42

  

ClinicalOut-come

Survival

97

865.10 (457.36–1277.47)

−3.534

0.000***

2.51 (0.28–11.04)

−3.642

0.000***

1.71 ± 1.52

3.7f

0.000***

Non-survival

26

1269.89 (955.25–2063.11)

  

37.16 (3.35–141.87)

  

1.84 ± 2.62

  
  1. ameans the mt-DNA value were compared between general sepsis group and normal groups
  2. bmeans the mt-DNA value were compared between general sepsis group and Severe sepsis groups
  3. cmeans the mt-DNA value were compared between general sepsis group and Non-sepsis infection groups
  4. dmeans the PCT value were compared between general sepsis group and Severe sepsis groups
  5. emeans the lactate value were compared between general sepsis group and Severe sepsis groups
  6. fmeans the Lactic value between survival group and non-survival groups were compared using t test
  7. * means P<0.05. ** means P<0.01, *** means P<0.001