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Table 4 Cut-off levels for procalcitonin, C-reactive protein and mean platelet volume in preterm neonatal sepsis subgroups

From: The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis

  Cut-off Sensitivity % (95% CI) Specificity % (95% CI) PPV % NPV% AUC p
EONS PCT 1 ng/mL 1.1 78.6 (69.1–86.2) 81.2 (75.4–86.1) 64.7 89.6 0.832 < 0.001
EONS PCT 2 ng/mL 0.48 83.7 (74.8–90.4) 67.3 (60.7–73.4) 52.9 90.4 0.801 < 0.001
EONS CRP 1 mg/L 2.6 80.6 (71.4–87.9) 83.0 (77.4–87.6) 67.5 90.7 0.838 < 0.001
EONS CRP 2 mg/L 2.6 59.2 (48.8–69.0) 83.0 (77.4–87.6) 60.4 82.2 0.696 < 0.001
EONS MPV 1 fL 7.9 61.2 (50.8–70.9) 54.3 (47.5–60.9) 37.0 76.1 0.563 0.073
EONS MPV 2 fL 8.2 69.4 (59.3–78.3) 66.4 (59.8–72.5) 47.6 83.1 0.704 < 0.001
LONS PCT 1 ng/mL 5.2 58.5 (48.5–68.0) 95.5 (91.9–97.8) 86.1 82.9 0.820 < 0.001
LONS PCT 2 ng/mL 1.1 60.4 (50.4–69.7) 81.2 (75.4–86.1) 60.4 81.2 0.745 < 0.001
LONS CRP 1 mg/L 3.6 78.3 (69.2–85.7) 87.4 (82.4–91.5) 74.8 89.4 0.856 < 0.001
LONS CRP 2 mg/L 2.4 69.8 (60.1–78.3) 80.3 (74.4–85.3) 62.7 84.8 0.791 < 0.001
LONS MPV 1 fL 8.4 60.4 (50.4–69.7) 72.2 (65.8–78.0) 50.8 79.3 0.689 < 0.001
LONS MPV 2 fL 8.4 75.5 (66.2–83.3) 72.2 (65.8–78.0) 56.3 86.1 0.786 < 0.001
Proven sepsis PCT 1 ng/mL 1.4 90.8 (83.3–95.7) 83.4 (77.9–88.0) 70.6 94.4 0.936 < 0.001
Proven sepsis PCT 2 ng/mL 1.1 75.5 (65.8–83.6) 81.2 (75.4–86.1) 63.8 88.3 0.829 < 0.001
Proven sepsis CRP 1 mg/L 7.0 76.5 (66.9–84.5) 98.2 (95.5–99.5) 94.9 90.5 0.922 < 0.001
Proven sepsis CRP 2 mg/L 2.6 70.4 (60.3–79.2) 83.0 (77.4–87.6) 64.5 86.4 0.771 < 0.001
Proven sepsis MPV 1 fL 7.9 73.5 (63.6–81.9) 54.3 (47.5–60.9) 41.4 82.3 0.653 < 0.001
Proven sepsis MPV 2 fL 8.9 71.4 (61.4–80.1) 82.5 (76.9–87.3) 64.2 86.8 0.811 < 0.001
Clinical sepsis PCT 1 ng/mL 1.2 57.6 (47.6–67.1) 82.1 (76.4–86.9) 60.4 80.3 0.724 < 0.001
Clinical sepsis PCT 2 ng/mL 0.5 67.9 (58.2–76.7) 67.3 (60.7–73.4) 49.7 81.5 0.720 < 0.001
Clinical sepsis CRP 1 mg/L 2.6 73.6 (64.1–81.7) 83.0 (77.4–87.6) 67.2 86.9 0.779 < 0.001
Clinical sepsis CRP 2 mg/L 2.4 59.4 (49.5–68.9) 80.3 (74.4–85.3) 58.9 80.6 0.722 < 0.001
Clinical sepsis MPV 1 fL 9.1 30.2 (21.7–39.9) 88.3 (83.4–92.2) 55.2 72.7 0.034 0.002
Clinical sepsis MPV 2 fL 8.1 72.6 (63.1–80.8) 62.3 (55.6–68.7) 47.8 82.7 0.686 < 0.001
  1. EONS Early onset neonatal sepsis, LONS Late onset neonatal sepsis, PPV Positive predictive value, NPV Negative predictive value, AUC Area under curve, PCT Procalcitonin, CRP C-reactive protein, MPV Mean platelet volume