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Table 4 Cut-off levels for procalcitonin, C-reactive protein and mean platelet volume in preterm neonatal sepsis subgroups

From: The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis

 

Cut-off

Sensitivity % (95% CI)

Specificity % (95% CI)

PPV %

NPV%

AUC

p

EONS PCT 1 ng/mL

1.1

78.6 (69.1–86.2)

81.2 (75.4–86.1)

64.7

89.6

0.832

< 0.001

EONS PCT 2 ng/mL

0.48

83.7 (74.8–90.4)

67.3 (60.7–73.4)

52.9

90.4

0.801

< 0.001

EONS CRP 1 mg/L

2.6

80.6 (71.4–87.9)

83.0 (77.4–87.6)

67.5

90.7

0.838

< 0.001

EONS CRP 2 mg/L

2.6

59.2 (48.8–69.0)

83.0 (77.4–87.6)

60.4

82.2

0.696

< 0.001

EONS MPV 1 fL

7.9

61.2 (50.8–70.9)

54.3 (47.5–60.9)

37.0

76.1

0.563

0.073

EONS MPV 2 fL

8.2

69.4 (59.3–78.3)

66.4 (59.8–72.5)

47.6

83.1

0.704

< 0.001

LONS PCT 1 ng/mL

5.2

58.5 (48.5–68.0)

95.5 (91.9–97.8)

86.1

82.9

0.820

< 0.001

LONS PCT 2 ng/mL

1.1

60.4 (50.4–69.7)

81.2 (75.4–86.1)

60.4

81.2

0.745

< 0.001

LONS CRP 1 mg/L

3.6

78.3 (69.2–85.7)

87.4 (82.4–91.5)

74.8

89.4

0.856

< 0.001

LONS CRP 2 mg/L

2.4

69.8 (60.1–78.3)

80.3 (74.4–85.3)

62.7

84.8

0.791

< 0.001

LONS MPV 1 fL

8.4

60.4 (50.4–69.7)

72.2 (65.8–78.0)

50.8

79.3

0.689

< 0.001

LONS MPV 2 fL

8.4

75.5 (66.2–83.3)

72.2 (65.8–78.0)

56.3

86.1

0.786

< 0.001

Proven sepsis PCT 1 ng/mL

1.4

90.8 (83.3–95.7)

83.4 (77.9–88.0)

70.6

94.4

0.936

< 0.001

Proven sepsis PCT 2 ng/mL

1.1

75.5 (65.8–83.6)

81.2 (75.4–86.1)

63.8

88.3

0.829

< 0.001

Proven sepsis CRP 1 mg/L

7.0

76.5 (66.9–84.5)

98.2 (95.5–99.5)

94.9

90.5

0.922

< 0.001

Proven sepsis CRP 2 mg/L

2.6

70.4 (60.3–79.2)

83.0 (77.4–87.6)

64.5

86.4

0.771

< 0.001

Proven sepsis MPV 1 fL

7.9

73.5 (63.6–81.9)

54.3 (47.5–60.9)

41.4

82.3

0.653

< 0.001

Proven sepsis MPV 2 fL

8.9

71.4 (61.4–80.1)

82.5 (76.9–87.3)

64.2

86.8

0.811

< 0.001

Clinical sepsis PCT 1 ng/mL

1.2

57.6 (47.6–67.1)

82.1 (76.4–86.9)

60.4

80.3

0.724

< 0.001

Clinical sepsis PCT 2 ng/mL

0.5

67.9 (58.2–76.7)

67.3 (60.7–73.4)

49.7

81.5

0.720

< 0.001

Clinical sepsis CRP 1 mg/L

2.6

73.6 (64.1–81.7)

83.0 (77.4–87.6)

67.2

86.9

0.779

< 0.001

Clinical sepsis CRP 2 mg/L

2.4

59.4 (49.5–68.9)

80.3 (74.4–85.3)

58.9

80.6

0.722

< 0.001

Clinical sepsis MPV 1 fL

9.1

30.2 (21.7–39.9)

88.3 (83.4–92.2)

55.2

72.7

0.034

0.002

Clinical sepsis MPV 2 fL

8.1

72.6 (63.1–80.8)

62.3 (55.6–68.7)

47.8

82.7

0.686

< 0.001

  1. EONS Early onset neonatal sepsis, LONS Late onset neonatal sepsis, PPV Positive predictive value, NPV Negative predictive value, AUC Area under curve, PCT Procalcitonin, CRP C-reactive protein, MPV Mean platelet volume
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BMC Pediatrics

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