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Table 4 Serum and urinary FGF23, IGFBP-7 and CysC levels grouped according to AKI status

From: Serum and urine FGF23 and IGFBP-7 for the prediction of acute kidney injury in critically ill children

Biomarker Non-AKI Mild AKI Severe AKI P
(n = 123) (n = 10) (n = 11)
sFGF23, pg/mL 79.33 [49.88–115.84] 59.97 [50.25–81.57] 92.33 [49.98–107.50] 0.372
sIGFBP-7, ng/mL 107.92 [87.47–125.02] 108.17 [83.65–135.71] 125.26 [103.07–148.35] 0.255
sCysC, mg/L 0.60 [0.47–0.78] 0.73 [0.54–0.96] 1.10 [1.06–1.72]*# < 0.001
uFGF23, pg/mg uCr 74.40 [39.20–225.8] 47.14 [28.82–130.6] 172.93 [114.37–448.25]*# 0.033
uIGFBP-7, ng/mg uCr 291.57 [135.60–539.04] 244.33 [87.51–478.73] 653.50 [301.94–2072.06]*# 0.005
uCysC, ng/mg uCr 183.17 [94.62–494.96] 122.38 [80.27–332.97] 6559.79 [1224.42–30,414.64]*# < 0.001
  1. Values are median [interquartile range]
  2. AKI network stage 1 was defined as mild AKI, and AKIN stages 2 and 3 were defined as severe AKI
  3. *P < 0.05, compared with non-AKI; #P < 0.05, compared with mild AKI