Effect of increased enteral protein intake on plasma and urinary urea concentrations in preterm infants born at < 32 weeks gestation and < 1500 g birth weight enrolled in a randomized controlled trial – a secondary analysis

Table 2 Comparison of the comorbidities of LPG and HPG

	LPG	HPG	p-value
NEC (≥ Bell stage 2A)	0(0)	0(0)	1
PDA therapy (indomethacin or ibuprofen)	4(13)	3(10)	1
BPD (physiological definition^a)	0(0)	2(7)	0,49
ROP^b/^c	0(0)	1(3)	1
IVH^d	3(10)	0(0)	0,24
PVL / intra-parenchymal bleeding	0(0) / 0(0)	0(0) / 0(0)	1 / 1
Corticosteroid administration inhaled / systemic^e	0(0) / 1(3)	5(17) / 1(3)	0,05 / 1

^amoderate or severe BPD indicated by need for positive pressure respiratory support or supplemental oxygen at a postmenstrual age of 36 weeks to maintain an SpO2 > 90%, verified by a room air test where indicated
^bno ophthalmologic examination in 6 patients
^cmax. Stage of ROP in all participants: stage I
^dmax. Grade of IVH in all participants: grade I
^ebudesonide inhalation, systemic supply of hydrocortisone (no patient received dexamethasone)

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