Trends in the incidence and associated factors of late-onset sepsis associated with improved survival in extremely preterm infants born at 23–26 weeks’ gestation: a retrospective study

Table 5 Unadjusted univariate analysis of associated factors for late-onset sepsis

Associated factors	23–24 weeks’ gestation	p-value	25–26 weeks’ gestation	p-value	23–26 weeks’ gestation	p-value
Associated factors	OR(95% CI) (n = 154)	p-value	OR(95% CI) (n = 210)	p-value	OR(95% CI) (n = 364)	p-value
Period II	0.620(0.297–1.294)	0.203	0.207(0.096–0.446)	< 0.001	0.381(0.229–0.634)	< 0.001
Gestational age, wk	1.036(0.489–2.193)	0.927	0.592(0.282–1.243)	0.166	0.721(0.562–0.924)	0.010
Body weight, 100 g	0.901(0.639–1.270)	0.552	0.871(0.663–1.143)	0.320	0.813(0.681–0.970)	0.021
Apgar score, 5 min	0.939(0.742–1.187)	0.598	0.709(0.571–0.880)	0.002	0.811(0.694–0.947)	0.008
Hospital stay, wk	1.006(0.969–1.044)	0.764	1.099(1.032–1.170)	0.003	1.036(1.003–1.070)	0.031
Intubation duration, wk	1.074(0.998–1.155)	0.055	1.168(1.050–1.299)	0.004	1.122(1.060–1.187)	< 0.001
Postnatal steroid use, wk	1.132(0.991–1.293)	0.067	1.322(1.049–1.666)	0.018	1.215(1.074–1.376)	0.002
Antibiotic use, wk	1.100(0.999–1.212)	0.053	1.355(1.164–1.578)	< 0.001	1.191(1.097–1.292)	< 0.001
Mortality	2.588(1.299–5.452)	0.012	1.234(0.387–3.936)	0.722	2.376(1.323–4.268)	0.004
NEC, ≥ stage 2b	3.434(1.286–9.172)	0.014	1.886(0.475–7.487)	0.367	3.105(1.437–6.711)	0.004
ROP, ≥ stage 3	1.483(0.710–3.100)	0.295	2.479(1.170–5.255)	0.018	2.022(1.199–3.411)	0.008

Bolded values indicate significant associated factors at p < 0.05
OR odds ratio, CI confidence interval, NEC necrotizing enterocolitis, ROP retinopathy of prematurity

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