Table 1 Summary of papers identified
Author | Study design | Title of article | Population(Location) and study setting | Year of enrolment | Original number enrolled and number followed up | Control and intervention | Primary outcome and tools used | Age of the children when outcome measured |
|---|---|---|---|---|---|---|---|---|
1. Zhou et al. 2006 [11] | RCT | Effect of iron supplementation during pregnancy on the intelligent quotient and behaviour of children at 4 years of age: long term follow up of a randomized controlled trial | AMBIT Women’s and children’s hospital, Adelaide, Australia Urban setting | Original trial 1997–1999 May 2002 Jan 2004 | 430 pregnant women enrolled IQ assessed I -153 C -149 Behaviour assessed I -151 C -149 | I = from 20wks of gestation to delivery birth 20 mg of iron C = placebo | Stanford Binet Intelligence Scale (SBIS) used to assess IQ and Strengths and Difficulties Questionnaire (SDQ) used to assess behaviour | 4 years |
2. Parsons et al. 2007 [20] | RCT | Effect of iron supplementation during pregnancy on the behaviour of children at early school age: long term follow up of a randomised control trial | Ditto | April to Nov 2006 | 430 pregnant women enrolled Behaviour assessed 264 I = 132 C - 132 | Ditto | Strength and Difficulties Questionnaire (SDQ) used to assess Behaviour | 6–8 years |
3. Li et al. 2009 [27] | Follow up of RCT | Effect of maternal multi-micronutrient supplementation on the mental development infants in rural Western China | China Rural setting of Shaanxi Province of Western China | Original research Aug 2002 to Jan 2006 Followed up from Jan 2004- Dec 2004 | 5828 women enrolled for the original trial and there were 4604 live births. For this component 1305 subset of infants assessed I – 471&396 C - 438 | Once pregnancy diagnosed but before 28 weeks of gestation I = FA 400+ Fe60 C = FA 400 | Bayle’s Scale of Infant development (BSID) used to assessed Mental & psychomotor development | 3, 6 & 12 month of age |
4. Chang et al. 2013 [26] | Effect of iron deficiency anaemia in pregnancy on child mental development in rural China | Ditto | 2004–2006 | 5828 women enrolled for the original trial and there were 4604 live births. For this component 1286 subset of children assessed C = 468 I-423 & 395 | I = FA 400 + Fe60 C = FA 400 | Bayley’s Scale of Infant development (BSID) used to assessed Mental Development Index and Psychomotor Development Index | 3, 6, 12, 18, & 24 months of age | |
5. Li et al. 2015 [28] | Follow up of RCT | Prenatal micronutrient supplementation is not associated with intellectual development of young school aged children | Ditto | 2012–2013 | For this component subset of 1744 children were assessed C -604 I -562 & 578 | I = FA 400+ Fe60. C = FA 400 | WISC-IV (Wechsler intelligence scale for Children Verbal comprehension scale, working memory index, perceptual reasoning, processing speed index | 7–9 years |
6. Christian et al. 2010 [12] | Follow up of RCT | Prenatal micronutrient supplementation and intellectual and motor function in early school aged children in Nepal | Nepal Rural setting of Southern Sarlahi district. | Original trial done from 1999 to 2001. Follow-up study from June 2007–April 2009 | 4998 women enrolled for the original and for this component 676 infants were enrolled. C -177. I -103 &178 7218 | From 11 weeks of gestation I = Fe60 + FA 60 + Vitamin A. C=Vitamin A | Universal Non Verbal Intelligence Test (UNVIT) | 7–9 years of age |
7. Angulo-Barroso et al. 2016 [18] | RCT | Iron supplementation in pregnancy or infancy and motor development: a RCT | China Rural setting of Hebei province. | June 2009 to Dec 2011. assessment done from Sep 2010 to Mar 2013 | 2371 recruited for the original study. I-1185. C- 1186 | From enrolment to birth I = Fe300 + FA. C = Placebo + FA | Peabody Development Motor Scale second edition PDMS II). Used to assess gross motor development | 9 months of age |