Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study

BMC Pediatrics

Table 2 Median values of angiogenic biomarkers and odds of death or bacteremia

Biomarker	Death (n = 18) median [IQR]	Survivor (n = 52) median [IQR]	aOR (95% CI)	p -value*	Bacteremia (n = 10) median [IQR]	Non-bacteremia (n = 30) median [IQR]	aOR (95% CI)	p -value*	Combined Outcome (n = 25) median [IQR]	Control (n = 73) median [IQR]	aOR (95% CI)	p -value*
Ang-1 (ng/mL)	11.7 [4.7, 21.5]	15.8 [10.5, 25.0]	0.51 (0.22, 1.19)	0.119	11.2 [6.0, 20.4]	14.7 [8.7, 26.2]	0.49 (0.17, 1.44)	0.194	11.2 [5.7, 20.4]	15.2 [8.9, 25.0]	0.54 (0.26, 1.10)	0.089
Ang-2 (ng/mL)	5.4 [3.1, 10.1]	3.3 [2.1, 4.1]	2.50 (1.13, 5.54)	0.024	4.1 [2.6, 6.1]	3.4 [1.2, 5.0]	6.12 (0.85, 44.00)	0.072	4.9 [2.8, 7.1]	3.3 [2.0, 4.1]	3.20 (1.40, 7.34)	0.006
Ang 2:1 ratio	0.48 [0.25, 0.87]	0.21 [0.10, 0.31]	2.29 (1.16, 4.46)	0.016	0.28 [0.20, 0.46]	0.20 [0.01, 0.31]	5.72 (1.07, 30.50)	0.041	0.28 [0.20, 0.46]	0.21 [0.01, 0.31]	2.56 (1.35, 4.87)	0.004
sICAM (ng/mL)	276.0 [160.9, 484.7]	197.2 [150.1, 346.8]	14.11 (1.4, 137.83)	0.023	265.1 [146.3, 398.8]	161.0 [125.0, 222.9]	26.72 (0.84, 846.9)	0.062	262.0 [146.3, 409.1]	179.9 [144.0, 272.6]	10.25 (2.04, 51.34)	0.005
sVCAM (ng/mL)	1236.6 [950.8, 1544.3]	1154.5 [884.6, 1071.0]	2.38 (0.56, 10.04)	0.239	1166.6 [795.2, 1410.3]	1149.9 [861.1, 1552.7]	1.66 (0.26, 10.67)	0.594	1289.7 [950.8, 1541.1]	1168.0 [886.2, 1647.3]	2.77 (0.80, 9.56)	0.149

aOR adjusted odds ratio, CI confidence interval, Ang-1 angiopoietin-1, Ang-2 angiopoietin-2, Ang2:1 ratio of Ang-2 to Ang-1, sICAM soluble intercellular adhesion molecule-1, sVCAM soluble vascular adhesion molecule 1, IQR inter-quartile range
*P-value for conditional logistic regression for sex, lethargy and prior antibiotic exposure for Death outcome; sex and prior antibiotic exposure for Bacteremia outcome; sex, lethargy, temperature and prior antibiotic exposure for combined outcome. Biomarkers were log transformed
Comparisons with p-value less than or equal to 0.05 marked in bold, and less than or equal to 0.10 marked in italics

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