Screening for glucose-6-phosphate dehydrogenase deficiency in neonates: a comparison between cord and peripheral blood samples

Table 1 Subgroup analysis of G6PD Quantitative Assay for Neonates with both Cord and Peripheral blood samples

Description		Cord	Peripheral blood	p-value
G6PD Quantitative Assay (U/g)				0.0008*
Overall		14.52	15.12
Mean		4.43	4.52
Incidence of G6PD % at two cut-off values	5.7 U/g	5.83	5.59	0.796^a
Incidence of G6PD % at two cut-off values	8.05 U/g	7.98	7.18	0.450
Mean G6PD Quantitative Assay (U/g Hgb), at 5.7 U/g cut-off	Deficient	1.45 ± 1.16	1.64 ± 1.27	0.3711
	Deficient	(n = 73)	(n = 70)	0.3711
	Non - Deficient	15.33 ± 3.09	15.92 ± 3.18	<0.001*
	Non - Deficient	(n = 1180)	(n = 1183)	<0.001*
Mean G6PD Quantitative Assay (U/g Hgb), at 8.05 U/g cut-off	Deficient	2.95 ± 2.68	2.85 ± 2.56	0.8001
	Deficient	(n = 100)	(n = 90)	0.8001
	Non - Deficient	15.52 ± 2.85	16.07 ± 3.01	<0.001*
	Non - Deficient	(n = 1153)	(n = 1163)	<0.001*

*Level of significance: p = < 0.05
The cord results are statistically lower than the peripheral results (p = 0.0008). This also holds true among the non-deficient subgroup of patients (p < 0.001) but NOT among the deficient neonates (p = 0.3711 and p = 0.8001 using cut-off of 5.7 and 8.05 U/g Hb respectively)
^aPearson chi² test did not reveal any significant difference in the proportion of G6PD deficient neonates between cord and peripheral blood samples

ISSN: 1471-2431