Table 3 Characteristics of studies included in child-relevant reviews, overall and for the 5 CRGs containing the largest number of child-relevant reviews
|  | Overall n = 1293 | Airways n = 148 | Cystic Fibrosis and Genetic Diseases n = 102 | Acute Respiratory Infections n = 100 | Developmental, Psychological, and Learning Problems n = 86 | Infectious Diseases n = 79 |
|---|---|---|---|---|---|---|
Study Designs | ||||||
 RCTs only (intended), n (% total) | 695 (57.7) | 123 (85.4) | 22 (78.6) | 66 (66.7) | 33 (39.8) | 44 (55.7) |
 RCTs only (actual), n (% of included studies) | 844 (73.5) | 123 (93.9) | 72 (98.6) | 62 (66.7) | 46 (66.7) | 53 (68.8) |
 RCTs and other designs (intended), n (% total) | 502 (41.7) | 19 (13.2) | 5 (17.9) | 33 (33.3) | 50 (60.2) | 33 (41.8) |
 RCTs and other designs (actual), n (% of included studies) | 270 (23.5) | 7 (5.3) | 1 (1.4) | 29 (31.2) | 23 (33.3) | 20 (26.0) |
 Non-RCTs (intended), n (% total) | 8 (0.7) | 2 (1.4) | 1 (3.6) | 0 (0.0) | 0 (0.0) | 2 (2.5) |
 Non-RCTs (actual), n (% of included studies) | 34 (3.0) | 1 (0.8) | 0 (0.0) | 2 (2.2) | 0 (0.0) | 4 (5.2) |
Studies and Participants | ||||||
 Number of studies included (median, IQR) | 8 (4, 17) | 8.5 (4, 21) | 4 (2, 8) | 8.5 (5, 18) | 8 (4, 11) | 10.5 (7, 21) |
 Reviews with no relevant studies, n (% of reviews in group) | 127 (9.8) | 17 (11.5) | 27 (26.5) | 4 (4.0) | 15 (17.9) | 1 (1.3) |
 Child only studies [% of total number of studies] | 21.2 | 26.3 | 24.5 | 31.9 | 19.6 | 34.6 |
 Adult only studies [% of total number of studies] | 25.2 | 26.3 | 9.1 | 15 | 3.4 | 17.7 |
 Mixed child and adult studies [% of total number of studies] | 17.1 | 24.3 | 42.4 | 8.3 | 9.1 | 30.7 |
 Number of participants included (median, IQR) | 980 (278, 3394) | 767 (234, 3747) | 213 (107, 397) | 1906 (618, 4414) | 746 (201, 1509) | 2730 (1283, 9128) |