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Table 3 Associations between infant weight gain and allergic outcomes by 18 months

From: Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life

  Quartile 1 Quartile 2 Quartile 3 Quartile 4 Q u arti l e 1 Quartile 2 Q uartile 3 Q u arti le 4  
Period of weight gain Allergic outcomes N(%) N(%) N(%) N(%) Reference
group
Adjusted OR (95% CI) Adjusted OR (95% CI) Adjusted OR (95% CI) p-trend
0 to 3 months Wheeze with a positive skin prick test 1 (0.6) 5 (3.0) 2 (1.3) 11 (7.6) 1.00 1.4 (0.1–17.9) 1.3 (0.1–18.6) 4.5 (0.4–53.4) 0.2
Prolonged rhinitis with a positive skin prick test 3 (1.9) 1 (0.7) 2 (1.4) 7 (5.2) 1.00 0.2 (0.0–3.0) 0.2 (0.0–3.4) 1.7 (0.2–14.5) 0.2
Atopic eczema with a positive skin prick test 5 (3.0) 4 (2.4) 2 (1.3) 9 (6.2) 1.00 0.4 (0.1–2.4) 0.3 (0.0–2.2) 0.8 (0.1–4.9) 0.8
Positive skin prick test 28 (14.1) 25 (14.0) 12 (6.7) 34 (19.3) 1.00 1.1 (0.5–2.4) 0.6 (0.2–1.4) 1.7 (0.7–3.9) 0.5
3 to 6 months Wheeze with a positive skin prick test 5 (3.2) 4 (2.5) 2 (1.3) 3 (1.9) 1.00 1.1 (0.1–8.5) 0.5 (0.0–6.5) 1.8 (0.3–12.4) 0.7
Prolonged rhinitis with a positive skin prick test 0 (0) 4 (2.8) 4 (2.9) 4 (2.9) 1.00 # # # #
Atopic eczema with a positive skin prick test 5 (3.1) 3 (1.8) 1 (0.7) 3 (2.0) 1.00 1.6 (0.2–10.6) # 1.0 (0.1–8.7) 0.6
Positive skin prick test 31 (17.6) 30 (16.8) 21 (12.4) 14 (8.3) 1.00 1.4 (0.7–3.0) 0.9 (0.4–2.0) 0.6 (0.2–1.4) 0.1
6 to 9 months Wheeze with a positive skin prick test 3 (1.9) 2 (1.2) 5 (3.1) 3 (2.0) 1.00 0.3 (0.0–3.6) 1.6 (0.3–9.7) 0.6 (0.1–7.9) 0.9
Prolonged rhinitis with a positive skin prick test 2 (1.4) 1 (0.7) 3 (2.1) 1 (0.8) 1.00 1.0 (0.1–12.6) 0.7 (0.1–9.6) 0.7 (0.0–11.4) 0.8
Atopic eczema with a positive skin prick test 5 (3.2) 4 (2.6) 1 (0.7) 1 (0.7) 1.00 2.4 (0.3–16.7) 0.6 (0.0–7.0) # 0.3
Positive skin prick test 30 (17.9) 26 (15.4) 22 (13.2) 16 (9.7) 1.00 0.5 (0.2–1.1) 0.5 (0.2–1.0) 0.3 (0.1–0.7) <0.01
9 to 12 m o n th s Wheeze with a positive skin prick test 3 (1.9) 1 (0.6) 3 (1.9) 0 (0) 1.00 0.7 (0.1–9.6) 1.8 (0.2–16.1) # 0.5
Prolonged rhinitis with a positive skin prick test 1 (0.7) 0 (0) 0 (0) 2 (1.3) 1.00 # # # #
Atopic eczema with a positive skin prick test 3 (2.0) 2 (1.3) 1 (0.7) 3 (2.0) 1.00 0.6 (0.0–7.0) 0.4 (0.0–4.9) # 0.2
Positive skin prick test 34 (20.0) 26 (15.8) 12 (7.3) 20 (11.3) 1.00 0.9 (0.4–1.8) 0.4 (0.2–0.96) 0.5 (0.2–1.2) 0.03
12 to 15 months Wheeze with a positive skin prick test 0 (0) 3 (1.7) 0 (0) 1 (0.6) 1.00 # # # #
Prolonged rhinitis with a positive skin prick test 0 (0) 0 (0) 0 (0) 0 (0) 1.00 # # # #
Atopic eczema with a positive skin prick test 1 (0.6) 0 (0) 0 (0) 2 (1.2) 1.00 # # # #
Positive skin prick test 32 (17.7) 25 (14.3) 19 (11.2) 20 (11.3) 1.00 0.7 (0.3–1.4) 0.5 (0.2–1.0) 0.4 (0.2–0.8) <0.01
  1. Weight gain at 0–3 months adjusted for birthweight for gestational age and sex, family history of allergy, ethnicity, sex, gestational age, breastfeeding, maternal education levels, maternal height and maternal BMI Weight gain (Kg) at 3–6 months, 6–9 months, 9–12 months and 12–15 months were adjusted for the baseline weight at the beginning of the period, family history of allergy, ethnicity, sex, breastfeeding, maternal education levels, maternal height and maternal BMI
  2. #Not estimable, owing to insufficient number of children with studied outcomes Effects of infant weight gain on allergic outcomes
  3. Values in italics have reached statistical significance with p-value <0.05