Recruited from bronchiolitis trial (N = 404) | Recruited from the general population (N = 238) | ||||||
---|---|---|---|---|---|---|---|
No. | No. | P value | |||||
Male sex, No. (%) | 404 | 240 | (59) | 238 | 133 | (56) | .2 |
Age at enrolment, mean (min, max), months | 404 | 4.2 | (0.2, 12.0) | 238 | 6.6 | (1.0, 13.4) | <.001 |
Age at two-year follow-up visit, mean (min, max), months | 294 | 24.6 | (19.0, 35.2) | 205 | 24.5 | (17.5, 35.2) | .83 |
Father Caucasian, No. (%) | 287 | 266 | (93) | 199 | 184 | (93) | .53 |
Mother Caucasian, No. (%) | 289 | 263 | (91) | 202 | 192 | (95) | .06 |
High parental education,a No. (%) | 351 | 245 | (70) | 238 | 219 | (92) | <.001 |
Low parental income,b No. (%) | 294 | 26 | (9) | 203 | 5 | (3) | .002 |
Firstborn child, No. (%) | 294 | 66 | (22) | 205 | 101 | (61) | <.001 |
One or more sibling living at home, No. (%) | 289 | 251 | (87) | 200 | 118 | (59) | <.001 |
Pet ownership,c No. (%) | 281 | 85 | (30) | 201 | 46 | (23) | .05 |
Parental atopy,d No. (%) | 293 | 213 | (73) | 205 | 152 | (74) | .40 |
Maternal atopy | 293 | 150 | (51) | 205 | 112 | (55) | .25 |
Paternal atopy | 293 | 120 | (41) | 205 | 86 | (42) | .45 |
Exposed to in-door smoking at home, No. (%) | 293 | 7 | (2) | 199 | 1 | (0.5) | .10 |
Gestational age, mean (min, max), weeks | 302 | 38.7 | (26, 42) | 223 | 39.6 | (28, 42) | <.001 |
Exclusive breastfeeding duration, mean (SD), months | 278 | 4.5 | (2.4) | 193 | 4.8 | (2.2) | .14 |
Any breastfeeding, mean (SD), months | 280 | 8.6 | (5.3) | 193 | 10.6 | (5.6) | <.001 |
Vitamin D level at enrolment, mean (min, max), nmol/l | 366 | 52.9 | (6.0, 132.0) | 229 | 66.5 | (6.0, 120.5) | <.001 |
Vitamin D level two-year follow-up visit, mean (min, max), nmol/l | 259 | 66.3 | (6.0, 142.9) | 191 | 67.8 | (16.6, 130.0) | .39 |
Filaggrin mutation,e No. (%) | 361 | 26 | (7) | 203 | 16 | (8) | .44 |
TEWLf at enrolment, median (Q1, Q3), g/m2/h | NA | NA | NA | 165 | 8.20 | (5.90, 10.43) | NA |
TEWLf at two-year follow-up visit, median (Q1, Q3), g/m2/h | 204 | 5.98 | (4.28, 9.20) | 156 | 5.08 | (3.28, 7.58) | .04 |