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Table 3 Gross Motor Function Measure and Muscle tone before and after stem cell transplantation

From: Outcomes of autologous bone marrow mononuclear cells for cerebral palsy: an open label uncontrolled clinical trial

 

Baseline

Mean [95% CI]

3 months post-transplantation

Mean [95% CI]

6 months post-transplantation

Mean [95% CI]

Total GMFM-88

16.7 [12.3; 21.1]

38.9 [32.2; 45.6]*

41.8 [34.8; 48.7]*

A. Lying & rolling

48.4 [41.2; 55.5]

87.8 [83.5; 92.1]*

91.7 [88.0; 95.3]*

B. Sitting

24.0 [16.5; 31.5]

55.1 [46.0; 64.3]*

59.5 [50.4; 68.7]*

C. Crawling & kneeling

8.7 [3.5; 13.8]

30.2 [18.9; 41.5]*

33.3 [21.4; 45.2]*

D. Standing

4.0 [0.9; 7.1]

17.9 [10.1; 25.7]*

20.2 [11.5; 28.8]*

E. Walking, running & jumping

1.2 [0.1; 2.4]

5.8 [2.2; 9.5]**

6.5 [2.5; 10.4]**

GMFM-66

24.8 [21.4; 28.1]

38.2 [34.6; 41.8]*

40.0 [36.3; 43.6]*

GMFM-66 percentiles

31.7 [24.9; 38.5]

82.3 [76.0; 88.5]*

84.6 [78.3; 90.8]*

Modified ashworth score

3.4 [3.2; 3.6]

2.1 [1.9; 2.3]*

2.0 [1.8; 2.2]*

  1. *p-value < 0.0001 (paired t-test, compared to baseline)
  2. **p-value = 0.001 (paired t-test, compared to baseline)