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Table 4 Area under the change from baseline versus time curve

From: A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients

AUC (0–2 h)

Acetaminophen

Intravenous Ibuprofen

N

50

46

Mean (SD)

-0.9 (0.89)

-1.5 (1.11)

Min, Max

-3.0, 0.7

-4.4, 0.1

p-value*

0.005

AUC (0–4 h)

Acetaminophen

Intravenous Ibuprofen

N

42

44

Mean (SD)

-2.6 (2.02)

-4.4 (2.59)

Min, Max

-7.4, 1.3

-12.0, 0.6

p-value*

<0.001

AUC (0–24 h)

Acetaminophen

Intravenous Ibuprofen

N

24

29

Mean (SD)

-26.6 (14.29)

-34.2 (17.97)

Min, Max

-66.1, 1.7

-72.9, 1.3

p-value*

0.099

  1. AUC area under the curve, Min minimum, Max maximum, N number, SD standard deviation
  2. *The analysis is based on an ANOVA model with fixed effects for treatment group
  3. The p-value and 95% confidence interval are based on the difference in LS Means from the ANOVA model