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Table 3 Biochemical parameters of patients and controls

From: Homocysteine metabolism in children and adolescents with epidermolysis bullosa

Analyte (reference interval or cut-off)

EB patients (n = 20)

Controls (n = 20)

p *

tHcya

(1 < 7 years; 2.7-7.6 μmol/L

7 < 12 years; 3.4 -8.4 μmol/L

12 < 15 years; M: 4.7-10.4 μmol/L; F: 4.1-10.4 μmol/L

15 < 19 years; M: 5.5-13.4 μmol/L; F: 4.9-11.9 μmol/L)

9.9;7.5-10.5

(55 %)

6.5;5.8-8.4

(15 %)

0.04

[0.02]

B12a

(1 < 9 years; 208.8- 1190 pmol/L

9 < 14 years; 185.9-830.2 pmol/L

14 < 17 years; 180.1-655.3 pmol/L

17 < 19 years; 149.8-598.5 pmol/L)

583.4;402.2-822.3

(0 %)

468.8;360.2-652.9

(5 %)

0.30

[1.00]

HoloTC

(>40 pmol/L)

99.2;79.7-128

(10 %)

84.9;51.1-128

(10 %)

0.42

[0.60]

s-Fb

(0-15 years; 11.6-33.2 nmol/L

15-65 years; 5.8-28.6 nmol/L)

11.1;8.4-21.3

(50 %)

13.1;11.1-15.7

(20 %)

0.64

[0.10]

ery-Fb

(2-15 years; 409.9-1162 nmol/L)

843.3;591.0-1559.7

(10 %)

608.4;556.3-742.5

(10 %)

0.10

[0.60]

B6b

(2-5 years; 10.0-21.6 μg/L

9-13 years; 9.6-24.4 μg/L)

6.9;4.2-12.3

(70 %)

11.3;9.2-14.3

(25 %)

0.03

[0.01]

hsCRP

(<0.5 mg/dL)

0.55;0.01-3.1

(50 %)

0.05;0.03-0.16

(0 %)

0.003

[0.00]

  1. Data are reported as median;IQR. Percentage of altered values are reported in parentheses (%). *Mann-Whitney test [chi-square test]
  2. a Bailey D. et al. [11]; b Ortega RM. et al. [12]. tHcy: total Homocysteine; B12: vitamin B12; HoloTC: Holotranscobalamin; s-F: serum Folate; ery-F: intraerythrocyte; B6: vitamin B6; hsCRP: high sensitive C Reactive Protein