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Table 2 Summary of baseline characteristics

From: Prolactin-related adverse events and change in prolactin levels in pediatric patients given antipsychotics for schizophrenia and schizophrenia spectrum disorders: A systematic review

Study N (ITT) Treatment Age, mean (SD) Male, n (%) Caucasian, n (%) Baseline prolactin, both sexes, (ng/mL), mean (SD) Baseline prolactin, males, (ng/mL), mean (SD) Baseline prolactin, females, (ng/mL), mean (SD) Previous antipsychotic use, n (%) Proportion diagnosed as paranoid schizophrenia, n (%) Baseline PANSS score, mean (SD)
Randomized controlled trials
Findling et al. 2012 [21] 73 Quetiapine 400 mg/day 15.5 (1.3) 43 (58.9) 45 (61.6) 20.8 (17.0) NR NR NR NR 96.2 (17.7)
74 Quetiapine 800 mg/day 15.5 (1.3) 44 (59.5) 44 (59.5) 18.1 (20.1) NR NR NR NR 97.0 (15.3)
73 Placebo 15.3 (1.4) 42 (57.5) 46 (63.0) 28.7 (29.1) NR NR NR NR 96.7 (18.0)
Findling et al. 2008 [22] 100 Aripiprazole 10 mg/day 15.6 (1.3) 45 (45.0) 5]4 (54.0) NR NR NR 53 (53.0) NR 93.7 (15.7)
102 Aripiprazole 30 mg/day 15.4 (1.4) 65 (63.7) 62 (60.8) NR NR NR 47 (46.1) NR 94.9(15.5)
100 Placebo 15.4 (1.4) 61 (61.0) 64 (64.0) NR NR NR 46 (46.0) NR 95.0(15.5)
Haas et al. 2009a [23] 55 Risperidone 1–3 mg/day 15.7 (1.3) 30 (54.5) 33 (60.0) 29.6 (38.2) 21.6 (15.2) 39.2 (53.0) NR 38 (69.1) NR
51 Risperidone 4–6 mg/day 15.7 (1.3) 37 (72.5) 24 (47.1) 24.1 (23.0) 22.7 (19.9) 27.9 (28.3) NR 34 (66.7) NR
54 Placebo 15.5 (1.4) 35 (64.8) 27 (50.0) 22.6 (23.3) 21.5 (21.1) 24.6 (25.9) NR 38 (70.4) NR
Haas et al. 2009b [26] 125 Risperidone 1.5–6 mg/day 15.6 (1.3) 65 (52.0) 104 (83.2) NR NR NR NR 83 (66.4) 96.4 (15.4)
132 Risperidone 0.15–0.6 mg/day 15.6 (1.3) 80 (60.6) 111 (84.9) NR NR NR NR 92 (69.7) 93.3 (14.1)
Kryzhanovskaya et al. 2009 [24] 72 Olanzapine 2.5–20 mg/day 16.1 (1.3) 51 (70.8) 52 (72.2) 15.6 (12.3) NR NR 51 (70.8) NR 95.3 (14.1)
35 Placebo 16.3 (1.6) 24 (68.6) 25 (71.4) 18.7 (16.2) NR NR 30 (85.7) NR 95.5 (14.1)
Singh et al. 2011 [25] 54 Paliperidone 1.5 mg/day 15.1 (1.5) 30 (55.6) 35 (64.8) 25.1 (32.8) 14.7 (14.5) 38.0 (45.5) 47 (87.0) NR 91.6 (12.5)
48 Paliperidone 3–6 mg/day 15.3 (1.6) 31 (64.6) 34 (70.8) 26.6 (43.2) 16.1 (1.8) 45.67 (71.0) 44 (91.7) NR 90.6 (14.0)
47 Paliperidone 6–12 mg/day 15.5 (1.6) 33 (70.2) 32 (68.1) 20.8 (22.3) 18.2 (13.7) 26.88 (33.9) 40 (85.1) NR 91.5 (13.9)
51 Placebo 15.7 (1.4) 23 (45.1) 35 (68.6) 24.5 (30.5) 13.6 (13.6) 33.43 (38.5) 48 (94.1) NR 90.6 (12.1)
Observational studies
Duval et al. 2008 [27] 16 Risperidone 1–6 mg/day 15.7 (1.3) 10 (62.5) 16 (100.0) 16 (9) NR NR NR NR NR
Kumra et al. 2008 [28] 14 Clozapine 25–900 mg/day 15.3 (2.3) 5 (35.7) 1 (7.1) NR NR NR 14 (100.0) NR NR
19 Olanzapine 30 mg/day 15.6 (1.7) 11 (57.9) 5 (26.3) NR NR NR 19 (100.0) NR NR
Pandina et al. 2012 [29] 48 Risperidone 2–6 mg/day (treatment-naïve) 15.4 (1.4) 30 (62.5) 25 (52.1) 17.0 (20.4) 18.6 (24.7) 14.3 (6.7) NR 33 (68.8) 84.7 (16.8)
292 Risperidone 2–6 mg/day (treatment-experienced) 15.5 (1.7) 178 (61.0) 218 (74.7) 53.4 (33.9) 40.4 (26.3) 73.6 (43.0) 292 (100.0) 195 (66.8) 72.1 (19.4)
50 Risperidone 2–6 mg/day (open-label) 15.5 (1.4) 30 (60.0) 42 (84.0) 73.6 (44.9) 55.8 (25.3) 100.3 (62.3) NR 35 (70.0) 83.9 (13.5)
Ruan et al. 2010 [30] 31 Risperidone 25–50 mg biweekly 15.9 (3.3) 13 (41.9) NR 54.8 (17.7) NR NR NR 24 (77.4) 57.8 (1.8)
Schimmelmann et al. 2007 [31] 56 Quetiapine 200–800 mg/day 15.9 (1.3) 38 (67.9) 47 (83.9) 15.9 (23.3) 12.6 (6.3) 22.9 (41.4) 13 (23.2) NR 91.5 (17.2)
  1. ITT Intention to treat, NR Not reported, SD Standard deviation
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