|
Randomized controlled trials
|
|
Findling et al. 2012 [21]
|
73
|
Quetiapine 400 mg/day
|
15.5 (1.3)
|
43 (58.9)
|
45 (61.6)
|
20.8 (17.0)
|
NR
|
NR
|
NR
|
NR
|
96.2 (17.7)
|
|
74
|
Quetiapine 800 mg/day
|
15.5 (1.3)
|
44 (59.5)
|
44 (59.5)
|
18.1 (20.1)
|
NR
|
NR
|
NR
|
NR
|
97.0 (15.3)
|
|
73
|
Placebo
|
15.3 (1.4)
|
42 (57.5)
|
46 (63.0)
|
28.7 (29.1)
|
NR
|
NR
|
NR
|
NR
|
96.7 (18.0)
|
|
Findling et al. 2008 [22]
|
100
|
Aripiprazole 10 mg/day
|
15.6 (1.3)
|
45 (45.0)
|
5]4 (54.0)
|
NR
|
NR
|
NR
|
53 (53.0)
|
NR
|
93.7 (15.7)
|
|
102
|
Aripiprazole 30 mg/day
|
15.4 (1.4)
|
65 (63.7)
|
62 (60.8)
|
NR
|
NR
|
NR
|
47 (46.1)
|
NR
|
94.9(15.5)
|
|
100
|
Placebo
|
15.4 (1.4)
|
61 (61.0)
|
64 (64.0)
|
NR
|
NR
|
NR
|
46 (46.0)
|
NR
|
95.0(15.5)
|
|
Haas et al. 2009a [23]
|
55
|
Risperidone 1–3 mg/day
|
15.7 (1.3)
|
30 (54.5)
|
33 (60.0)
|
29.6 (38.2)
|
21.6 (15.2)
|
39.2 (53.0)
|
NR
|
38 (69.1)
|
NR
|
|
51
|
Risperidone 4–6 mg/day
|
15.7 (1.3)
|
37 (72.5)
|
24 (47.1)
|
24.1 (23.0)
|
22.7 (19.9)
|
27.9 (28.3)
|
NR
|
34 (66.7)
|
NR
|
|
54
|
Placebo
|
15.5 (1.4)
|
35 (64.8)
|
27 (50.0)
|
22.6 (23.3)
|
21.5 (21.1)
|
24.6 (25.9)
|
NR
|
38 (70.4)
|
NR
|
|
Haas et al. 2009b [26]
|
125
|
Risperidone 1.5–6 mg/day
|
15.6 (1.3)
|
65 (52.0)
|
104 (83.2)
|
NR
|
NR
|
NR
|
NR
|
83 (66.4)
|
96.4 (15.4)
|
|
132
|
Risperidone 0.15–0.6 mg/day
|
15.6 (1.3)
|
80 (60.6)
|
111 (84.9)
|
NR
|
NR
|
NR
|
NR
|
92 (69.7)
|
93.3 (14.1)
|
|
Kryzhanovskaya et al. 2009 [24]
|
72
|
Olanzapine 2.5–20 mg/day
|
16.1 (1.3)
|
51 (70.8)
|
52 (72.2)
|
15.6 (12.3)
|
NR
|
NR
|
51 (70.8)
|
NR
|
95.3 (14.1)
|
|
35
|
Placebo
|
16.3 (1.6)
|
24 (68.6)
|
25 (71.4)
|
18.7 (16.2)
|
NR
|
NR
|
30 (85.7)
|
NR
|
95.5 (14.1)
|
|
Singh et al. 2011 [25]
|
54
|
Paliperidone 1.5 mg/day
|
15.1 (1.5)
|
30 (55.6)
|
35 (64.8)
|
25.1 (32.8)
|
14.7 (14.5)
|
38.0 (45.5)
|
47 (87.0)
|
NR
|
91.6 (12.5)
|
|
48
|
Paliperidone 3–6 mg/day
|
15.3 (1.6)
|
31 (64.6)
|
34 (70.8)
|
26.6 (43.2)
|
16.1 (1.8)
|
45.67 (71.0)
|
44 (91.7)
|
NR
|
90.6 (14.0)
|
|
47
|
Paliperidone 6–12 mg/day
|
15.5 (1.6)
|
33 (70.2)
|
32 (68.1)
|
20.8 (22.3)
|
18.2 (13.7)
|
26.88 (33.9)
|
40 (85.1)
|
NR
|
91.5 (13.9)
|
|
51
|
Placebo
|
15.7 (1.4)
|
23 (45.1)
|
35 (68.6)
|
24.5 (30.5)
|
13.6 (13.6)
|
33.43 (38.5)
|
48 (94.1)
|
NR
|
90.6 (12.1)
|
|
Observational studies
|
|
Duval et al. 2008 [27]
|
16
|
Risperidone 1–6 mg/day
|
15.7 (1.3)
|
10 (62.5)
|
16 (100.0)
|
16 (9)
|
NR
|
NR
|
NR
|
NR
|
NR
|
|
Kumra et al. 2008 [28]
|
14
|
Clozapine 25–900 mg/day
|
15.3 (2.3)
|
5 (35.7)
|
1 (7.1)
|
NR
|
NR
|
NR
|
14 (100.0)
|
NR
|
NR
|
|
19
|
Olanzapine 30 mg/day
|
15.6 (1.7)
|
11 (57.9)
|
5 (26.3)
|
NR
|
NR
|
NR
|
19 (100.0)
|
NR
|
NR
|
|
Pandina et al. 2012 [29]
|
48
|
Risperidone 2–6 mg/day (treatment-naïve)
|
15.4 (1.4)
|
30 (62.5)
|
25 (52.1)
|
17.0 (20.4)
|
18.6 (24.7)
|
14.3 (6.7)
|
NR
|
33 (68.8)
|
84.7 (16.8)
|
|
292
|
Risperidone 2–6 mg/day (treatment-experienced)
|
15.5 (1.7)
|
178 (61.0)
|
218 (74.7)
|
53.4 (33.9)
|
40.4 (26.3)
|
73.6 (43.0)
|
292 (100.0)
|
195 (66.8)
|
72.1 (19.4)
|
|
50
|
Risperidone 2–6 mg/day (open-label)
|
15.5 (1.4)
|
30 (60.0)
|
42 (84.0)
|
73.6 (44.9)
|
55.8 (25.3)
|
100.3 (62.3)
|
NR
|
35 (70.0)
|
83.9 (13.5)
|
|
Ruan et al. 2010 [30]
|
31
|
Risperidone 25–50 mg biweekly
|
15.9 (3.3)
|
13 (41.9)
|
NR
|
54.8 (17.7)
|
NR
|
NR
|
NR
|
24 (77.4)
|
57.8 (1.8)
|
|
Schimmelmann et al. 2007 [31]
|
56
|
Quetiapine 200–800 mg/day
|
15.9 (1.3)
|
38 (67.9)
|
47 (83.9)
|
15.9 (23.3)
|
12.6 (6.3)
|
22.9 (41.4)
|
13 (23.2)
|
NR
|
91.5 (17.2)
|
