Table 1 Main demographic and clinical characteristics of FAS population (N = 30) at inclusion

Boys, N (%)

18 (60.0)

Age, mean (± SD), months

4.8 (3.0)

Gestational age, mean (± SD), weeks

38.7 (1.0)

WFA z-score at birth, mean (± SD)

−0.1 (1.1)

LFA z-score at birth, mean (± SD)

0.0 (1.3)

Feeding history

Ever breastfed, N (%)

25 (83.3)

Duration of exclusive breastfeeding, mean (± SD), weeks

11.5 (7.7)

Duration of partial breastfeeding, mean (± SD), weeks

8.5 (6.1)

Type of feeding at study entry, N (%)

 Exclusively formula-fed

29 (96.7)

 Partially breast-fed^a

1 (3.3)

Type of formula used before study inclusion, N (duration of use, mean ± SD, weeks)

 Non-hydrolyzed CMP-based formula

6 (8.5 ± 5.0)

 Extensively hydrolyzed formula based on CMP

13 (6.2 ± 8.8)

 Amino acid-based formula

6 (2.7 ± 1.1)

 Vegetable-based formula

5 (2.6 ± 2.1)

WFA z-score, mean (± SD)

−0.8 (0.8)

LFA z-score, mean (± SD)

−0.7 (1.0)

WFL z-score, mean (± SD)

−0.4 (1.1)

BMI-for-age z-score, mean (± SD)

−0.6 (1.0)

HCA z-score, mean (± SD)

−0.3 (1.2)

Allergy characteristics

Family history of allergy‡, N (%)

10 (33.3)

Age at onset of allergy symptoms, mean (± SD), months

2.5 (2.3)

Time since the start of the exclusion diet, median [min – max; IQR], weeks

2.7 [0.0–36.0; 1.1–6.3]

Delay between onset of allergy symptoms and start of exclusion diet, median [min – max; IQR], weeks

1.3 [0.0–34.9; 0.6–4.1]

Types of first allergy symptoms, N (%)

 Exclusively digestive

17 (56.7)

 Exclusively cutaneous

10 (33.3)

 At least two concerned areas

3 (10.0)

CMA diagnosis tests, number of subjects with positive reactions/number of subjects with test performed (%)

 Atopy patch test to CMP

8/18 (44.4)

 Skin prick test to CMP

20/30 (66.7)

 Serum IgE specific to CMP

3/6 (50.0)