Grade | Skin | GI tract | Respiratory tract | Cardiovascular | Neurological |
---|---|---|---|---|---|
1 | Localized pruritus, flushing, urticaria, angioedema | Oral pruritis, mild lip swelling | None | None | None |
2 | Generalized pruritus, flushing, urticaria, angioedema | Any of the above, Nausea and or emesis x’s 1 | Nasal congestion and/or sneezing | None | Change in activity level |
3 | Any of the above | Any of the above plus repetitive vomiting | Rhinorrhea, marked congestion, sensation of throat pruritus of tightness | Tachycardia | Change in activity level plus anxiety |
4 | Any of the above | Any of the above plus diarrhea | Any of the above, hoarseness, “barky”cough, difficulty swallowing, dyspnea, wheezing, cyanosis | Any of the above, dysrhythmia and or mild hypotension | “light headedness”, feeling of “pending doom” |
5 | Any of the above | Any of the above, loss of bowel control | Any of the above, respiratory arrest | Severe bradycardia and/or hypotension or cardiac arrest | Loss of consciousness |