Table 4 Change in biochemical status and clinical parameters according to cobalamin intervention at 6 months and follow-up at 7 months

Number

16/16

16/15

Serum cobalamin, pmol/L, (median (IQR)), %change

707 (422, 904), 254 %

33 (-17, 74), 10 %

<0.001^a

Plasma total homocysteine, μmol/L, (median (IQR)), %change

-5.85 (-7.48, -4.37), -61 %

-1.02 (-1.81, -0.23), -13 %

<0.001^a

Plasma methylmalonic acid, μmol/L, (median (IQR)), %change

-0.88 (-2.01, -0.12), -113 %

-0.07 (-0.33, 0.29), -14 %

0.001^a

Serum folate, nmol/L, (median (IQR)), %change

-16.1 (-30.4, -2.5), -37 %

-14.0 (-16.8, -2.9), -29 %

<0.44^a

Plasma PLP, μmol/L, (median (IQR)), %change

12 (-24, 38), 9 %

0 (-22, 61), 0 %

<0.98^a

Plasma riboflavin, μmol/L, (median (IQR)), %change

0.3 (-4.8, 2.7), 2 %

3.7 (-3.5, 8.4), 3 %

<0.32^a

AIMS score, (median (IQR)), %change

7.0 (5.3, 9.8), 36 %

5.0 (4.0, 7.0), 23 %

0.02^a

ASQ; Gross motor score (median (IQR)), %change^c

12.5 (10.0, 16.3), 42 %

10.0 (-1.3, 10.0), 29 %

0.03^a

Weight, gram, (mean (SD)), %change

532 (230), 8 %

377 (257), 6 %

0.09^b

Length, cm, (mean (SD)), %change

2.0 (1.3), 3 %

1.8 (1.1), 3 %

0.81^b

Head circumference, cm, (mean (SD)), %change

0.8 (0.7), 2 %

0.8 (0.4), 2 %

0.89^b