Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

Table 4 Prevalence of NP carriage of OM pathogens in NP-swabbed children, by vaccination group

	PCV7		PHiD-CV10		Absolute Risk Difference	P value
	PCV7		PHiD-CV10		[95 % CI]	P value
	n/N	%	n/N	%
NP carriage
NTHi	284/420	68 %	322/440	73 %	6 %	0.07
NTHi	284/420	68 %	322/440	73 %	[−0.5 to 12]	0.07
Spn	321/420	76 %	359/440	82 %	5 %	0.06
Spn	321/420	76 %	359/440	82 %	[−0.2 to 11]	0.06
Mcat	202/420	48 %	189/438	43 %	−5 %	0.15
Mcat	202/420	48 %	189/438	43 %	[−12 to 2]	0.15
Sa	136/420	32 %	94/440	21 %	−11 %	0.0003
Sa	136/420	32 %	94/440	21 %	[−17 to −5]	0.0003
Combination NP carriage categories
Spn and NTHi	267/420	64 %	297/440	68 %	4 %	0.23
Spn and NTHi	267/420	64 %	297/440	68 %	[−2 to 10]	0.23
Spn or NTHi	361/420	86 %	400/440	91 %	5 %	0.02
Spn or NTHi	361/420	86 %	400/440	91 %	[0.6 to 9]	0.02
PCV7 types	38/319	12 %	31/372	8 %	−4 %	0.12
PCV7 types	38/319	12 %	31/372	8 %	[−8 to1]	0.12
PCV13 types	92/319	29 %	77/372	21 %	−8 %	0.01
PCV13 types	92/319	29 %	77/372	21 %	[−15 to −2]	0.01
Serotypes^b	16F^cd(12 %) 19A^cd(10 %) 11A^cde 23B^cde 6C^c = 19F^de 23F^cde = 6A^a = 10A^d 33F		16F^d(14 %) 19A^de(8 %) 11A^de 10A^d 6C^c 15A^de 23F^cde 21^c 23B^d 35F
	Non-mixed PCV schedules
NP carriage	333^a		314
NTHi	225/332	68 %	230/314	73 %	5 %	0.13
NTHi	225/332	68 %	230/314	73 %	[−2 to 12]	0.13
Spn	253/332	76 %	259/314	82 %	6 %	0.05
Spn	253/332	76 %	259/314	82 %	[0 to 12]	0.05
Mcat	172/332	52 %	127/313	41 %	−11 %	0.004
Mcat	172/332	52 %	127/313	41 %	[−19 to −4]	0.004
Sa	105/332	32 %	70/314	22 %	−9 %	0.008
Sa	105/332	32 %	70/314	22 %	[−16 to −2]	0.008

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