Lung function in very preterm infants with patent ductus arteriosus under conservative management: an observational study

Table 1 The clinical characteristics of the study infants

	PDA^a	No-PDA	P-value
	(n = 28)	(n = 20)	P-value
Birth weight, kg	0.98 ± 0.26	1.12 ± 0.26	0.074
Gestational age, weeks	27.1 ± 2.0	28.6 ± 1.6	0.009
Male, n (%)	14 (50)	11 (55)	0.733
Antenatal steroid use, n (%)	15 (53.6)	12 (60)	0.658
Intubation after birth, n (%)	20 (71.4)	8 (40)	0.029
RDS, Grade 3 or 4, n (%)	14 (50)	6 (30)	0.166
Exogenous surfactant use, n (%)	8 (28.6)	2 (10)	0.118
Days of invasive ventilation	22.2 ± 28.1	1.6 ± 2.3	0.008
Total days of respiratory support	66.8 ± 25.6	40.8 ± 21.8	0.001
O2 dependence at 28 days, n (%)	25 (89.3)	14 (70)	0.092
BPD, n (%)	21 (75)	6 (30)	0.002
ROP, ≥ stage 3, n (%)	7 (25)	2 (10)	0.189
NEC, n (%)	0 (0)	2 (10)	0.087
IVH, any grade, n (%)	11 (39.3)	5 (25)	0.301
Pneumothorax, n (%)	4 (14.3)	0 (0)	0.136

^aPDA with conservative treatment
All continuous data are presented as mean ± SD
RDS respiratory distress syndrome; BPD bronchopulmonary dysplasia; ROP retinopathy of prematurity; NEC necrotizing enterocolitis; IVH intraventricular hemorrhage

ISSN: 1471-2431