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Table 2 Characteristics of all 4 neonates with SCFN

From: Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register

SCFN Case 1 Case 2 Case 3 Case 4
Sex Female Female Male Female
Gestationalage[weeks] 38 2/7 40 2/7 39 1/7 40 0/7
Birth weight [grams] 3920 3480 3400 3190
Mode of delivery Emergency caesarian section Instrumental delivery Instrumental delivery Emergency caesarian section
Age at appearance of SCFN [days] 16 3 6 4
Cooling method applied Passive plus ice packs Passive plus ice packs Active (Criticool System) Active (Criticool System)
Localization of SCFN Left scapula region and dorsal upper arm Back Back Upper back
Appearance of SCFN Red nodules, plaques Red nodules, plaques Palpablenodules, plaques Red nodules, plaques
Diagnosis by Neonatologist Neonatologist Neonatologist Neonatologist
Therapy Conservative Conservative Conservative Hydration, low calcium formula, no vitamin D supplementation, analgesia
Thrombocytopenia No No No No
Hypoglycemia No No No No
Calcium level ionized (total) [mmol/l] 1.41 (2.49) 1.33 1.5 1.54 (2.77)
Follow-up Yes Yes Yes Yes
Who Pediatrician, pediatric surgeon Pediatrician Pediatrician Pediatrician, endocrinologist
Examination Clinical follow-up Clinical follow-up and calcium level Clinical follow-up Clinical follow-up, calcium level and ultrasound of kidneys
  1. SCFN subcutaneous fat necrosis calcium level: routinely ionized calcium is measured