Table 3 Outcome measures for antenatally, postnatally diagnosed HLHS
Hypoplastic left heart syndrome | Antenatal diagnosis | Postnatal diagnosis | OR (95% CI) or p-value | |
|---|---|---|---|---|
Liveborn cases | 16 | 6 | ||
Case status | ||||
Liveborn - alive: | 10 | 5 | ||
Liveborn - later died: | 6 | 1 | ||
Postnatal | Median Apgar Score | 9 | 9 | n/a |
Pre-operative Acidosis, n(%) | 12 (75.0) | 6 (100.0) | 4.68 (0.21 - 100.99) | |
Intubation, n(%) | 5 (31.3) | 5 (83.3) | 11 (1.00 - 120.44) | |
Mortality within first week, n(%) | 0 (−) | 1 (16.7) | n/a | |
Surgical | Attempted Surgery, n | 15 | 5 | n/a |
Median Age at Surgery (IQR), days | 3.5 (3–7.5) | 7 (5–21.5) | p = 0.16 | |
Median Weight at Surgery (IQR), gram | 3060 (2900–3510) | 3900 (2360–4200) | n/a | |
Median Bypass Time (IQR), mins | 153 (123.5 - 192.5) | 134 (117–151) | n/a | |
Length of ICU Stay Post Surgery, days | 16.5 (7–27.5) | 11 (8–14.5) | n/a | |
Long-term outcome | 30 day survival (all Liveborn) | 75.0% (12/16) | 83.3% (5/6) | 0.60 (0.05 - 6.80) |
1 Year survival (all Liveborn) | 62.5% (10/16) | 83.3% (5/6) | 0.33 (0.31 - 3.58) | |
3 Year survival (all Liveborn <2010) | 76.9% (10/13) | 80.0% (4/5) | 0.83 (0.66 - 10.60) | |
5 Year survival (all Liveborn <2008) | 75.0% (6/8) | 75.0% (3/4) | n/a | |
10 Year Survival (all Liveborn <2003) | - (0/0) | 50.0% (1/2) | n/a | |
Documented neurodevelopment issues, n | 4/10 | 2/5 | p = 1.00 | |
Cases requiring on-going cardiac medication, n | 9/9 | 4/4 | n/a | |
Cases with ongoing cardiac symptoms (All), n | 8/10 | 1/4 | 0.08 (0.01 - 1.29) | |
Cases with ongoing cardiac symp. (Fontan), n | 3/4 | 1/3 | n/a | |