Trends in paediatric bloodstream infections at a South African referral hospital

BMC Pediatrics

Table 3 Bloodstream infection-associated mortality

BSI-associated mortality	Number (n)	Percentage (%)	p-value
Total BSI-associated deaths	176	100	-
Male	97	55.1	0.49
Median age (months) IQR	7.2	IQR 3–14.7	-
HIV status
- Positive	34	19.3
- Negative	87	49.4	0.03
- Unknown	55	31.3
Onset of BSI ^#
- Community-acquired	75/460	16.3	0.002
- Hospital-acquired	101/404	25
Factors associated with mortality from BSI
Variable assessed	Univariate analysis (p-value)	Multivariate analysis (p-value)	Odds ratio	95% CI
Length of stay prior to BSI onset	<0.001	0.11	-	-
Age category	0.13	0.44	-	-
Gender	0.49	0.32	-	-
HIV status (positive)	0.03	0.02	1.74	1.1 - 2.8
Year of BSI	0.89	0.78	-	-
Place of BSI onset (hospital-acquired)	0.002	0.04	1.43	1.1 - 2.0
Type of BSI pathogen	0.001	0.03
- Fungal			2.10	1.1 – 4.2
- Gram negative			1.88	1.2 – 2.9
Mono- vs poly-microbial BSI	0.72	0.6	-	-
ICU vs general ward at BSI onset	<0.001	0.001	2.93	1.9 – 4.4
Antimicrobial resistance	0.06	0.83	-	-

BSI = bloodstream infection; ICU = intensive care unit; ^#CA-BSI = BC submitted within first 72 hours of admission; HA-BSI = BC submitted > 72 hours after admission. To determine factors associated with mortality from BSI and antimicrobial resistance, binary logistic regression analyses were performed. A p-value below 0.05 was considered statistically significant.

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