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Table 2 Sensitivity, specificity, predictive values and likelihood ratios of CRP and RNSOS as a single test and when in combination

From: Management of neonatal sepsis at Muhimbili National Hospital in Dar es Salaam: diagnostic accuracy of C – reactive protein and newborn scale of sepsis and antimicrobial resistance pattern of etiological bacteria

  Sensitivity (C.I) Specificity (C.I) PPV (C.I) NPV (C.I) LHR + ve test (C.I) LHR - ve test (C.I) P value
RNSOS 65% (48 – 79.4) 79.7% (72.9 – 85.5) 43.3% (30.6 – 56.8) 90.5% (84.6 – 94.7) 3.24 (2.2 – 4.68) 0.45 (0.28 – 0.64) <0.01
CRP1 87.5% (73.25 – 95.81) 70.8% (63.3 – 77.58) 41.7% (31 – 52.97) 95.9% (90.84 – 98.68) 3 (2.3 – 3.9) 0.18 (0.08 – 0.4) <0.01
CRP2 78.9% (62.7 – 90.5) 75.8% (68 – 81.7) 42.3% (30.6 – 64.6) 93.9% (88.5 – 97.3) 3.2 (2.3 – 4.3) 0.27 (0.15 – 4.3) <0.01
CRP 1 + CRP 2 75.7% (58.8 – 88.2) 92.9% (87.9 – 96.2) 70% (53.4 – 83.4) 94.5 (89.9 – 97.4) 10.6 (4.1 – 17.1) 0.26 (0.10 – 0.42) <0.01
RNSOS + CRP 1 95.6% (90.0 – 97.5) 56.4% (38.7 – 70.7) 71% (51.9 – 85.7) 89.8 (84.4 – 93.8) 10.3 (2.7 –17.8) 0.47 (0.3 – 0.65) 0.01
RNSOS + serial CRP 47.5% (31.5 – 63.8) 96.4% (92.4 – 98.7) 76% (54.8 – 92.7) 88.5% (83 – 92.7) 13.3 (1.3 – 25.3) 0.54 (0.37 – 0.72) 0.03
  1. C.I- confidence interval, CRP - C- reactive protein, RNSOS - Rubarth’s newborn scale of sepsis, PPV - Positive predictive value, NPV -negative predictive value, LHR - likelihood ratio.