Table 2 Sensitivity, specificity, predictive values and likelihood ratios of CRP and RNSOS as a single test and when in combination

RNSOS

65% (48 – 79.4)

79.7% (72.9 – 85.5)

43.3% (30.6 – 56.8)

90.5% (84.6 – 94.7)

3.24 (2.2 – 4.68)

0.45 (0.28 – 0.64)

<0.01

CRP1

87.5% (73.25 – 95.81)

70.8% (63.3 – 77.58)

41.7% (31 – 52.97)

95.9% (90.84 – 98.68)

3 (2.3 – 3.9)

0.18 (0.08 – 0.4)

<0.01

CRP2

78.9% (62.7 – 90.5)

75.8% (68 – 81.7)

42.3% (30.6 – 64.6)

93.9% (88.5 – 97.3)

3.2 (2.3 – 4.3)

0.27 (0.15 – 4.3)

<0.01

CRP ₁  + CRP ₂

75.7% (58.8 – 88.2)

92.9% (87.9 – 96.2)

70% (53.4 – 83.4)

94.5 (89.9 – 97.4)

10.6 (4.1 – 17.1)

0.26 (0.10 – 0.42)

<0.01

RNSOS + CRP ₁

95.6% (90.0 – 97.5)

56.4% (38.7 – 70.7)

71% (51.9 – 85.7)

89.8 (84.4 – 93.8)

10.3 (2.7 –17.8)

0.47 (0.3 – 0.65)

0.01

RNSOS + serial CRP

47.5% (31.5 – 63.8)

96.4% (92.4 – 98.7)

76% (54.8 – 92.7)

88.5% (83 – 92.7)

13.3 (1.3 – 25.3)

0.54 (0.37 – 0.72)

0.03