| Baseline | 3 months | 6 months | 12 months | ||||
---|---|---|---|---|---|---|---|---|
n = 111 | n = 106 | n = 100 | n = 85 | |||||
Acanthosis nigricans present | 94 | (84.7) | 88 | (83.8)* | 79 | (85.9)* | 61 | (76.3)* |
Pre-diabetes | 14 | (12.6) | 19 | (17.9) | Â | Â | 10 | (12.1)*,** |
Dyslipidaemia | 61 | (55.0)* | 57 | (54.3)* | 51 | (53.7)| | 32 | (28.8)* |
(HDL-C <1.03 mmol/L and/or triglycerides ≥1.7 mmol/L) | ||||||||
SBP and/or DBP ≥90 percentile | 49 | (44.1) | 41 | (38.7) | 30 | (30.6)* | 37 | (43.5) |
Elevated liver enzymes (ALT and/or GGT ≥1.5 upper limit of 30 U/L) | 22 | (20.0)* | 21 | (20.4)* | 17 | (17.3)* | 14 | (12.6)* |
Microalbuminuria | 9 | (8.5)* | 9 | (8.9)* | 9 | (9.5)* | 9* | (8.1)* |
(Urine/albumin/creatinine, Girls: 3.5 to 25 mg/mmol, Boys: 2.5 to 25 mg/mmol) |