Table 7 Reporting of Early Termination Parameters in Trials Terminated Early (n = 32)^†

Motive(s) for termination*

   Adequately reported

18 (100)

12 (86)

   Terminated for efficacy

3 (17)

3 (21)

   Terminated for harm

2 (11)

4 (29)

   Terminated for futility

3 (17)

4 (29)

   Other reasons reported (stand-alone or additional)

13 (72)

2 (14)

Rationale for termination

(i.e. stopping guidelines/rules)

   Reported

15 (73)

13 (93)

   Unclear or Not Reported

3 (17)

1 (7)

DMC role in early termination

   Reported

3 (17)

12 (86)

   Unclear or Not Reported

15 (83)

2 (14)

Timing of early termination ^#

   Reported

8 (44)

8 (57)

   Unclear or Not Reported

10 (56)

6 (43)

Adjustment of results for interim analysis (p value, CI or estimate)

   Reported

2 (11)

8 (57)

   Unclear or Not Reported

16 (89)

6 (43)

Section of paper where reference to early termination was reported

   Title/Abstract

4 (22)

5 (36)

   Methods

14 (78)

14 (100)

   Results

13 (72)

6 (43)

   Discussion

10 (56)

3 (21)