A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials

Table 1 Reporting of Data Monitoring Committees (DMCs) or Interim Analysis or Early Termination: Data on Included Randomized Controlled Trials (RCTs), and Total Number of Published RCTs, per Journal, from 2005 to 2007*

Journal	RCTs Reporting DMC or Interim/Total RCTs	RCTs Reporting Early Termination/Total RCTs
General Journals
BMJ	3/62 (5%)	1/62 (2%)
JAMA	11/24 (46%)	1/24 (4%)
Lancet	23/83 (28%)	9/83 (11%)
N Engl J Med	31/80 (39%)	3/80 (4%)
Total	68/249 (27%)	14/249 (6%)
Pediatric Journals
Arch Dis Child	2/37 (5%)	2/37 (5%)
Arch Ped Adolesc Med	4/61 (7%)	2/61 (3%)
J Pediatr	7/88 (8%)	3/88 (3%)
Pediatrics	24/213 (11%)	11/213 (5%)
Total	37/399 (9%)	18/399 (5%)

*The denominator refers to the total number of pediatric trials for each journal during the studied time period, which was obtained using Medline's filters (publication type "randomized controlled trial" and age category "0-18 years").