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Table 1 Reporting of Data Monitoring Committees (DMCs) or Interim Analysis or Early Termination: Data on Included Randomized Controlled Trials (RCTs), and Total Number of Published RCTs, per Journal, from 2005 to 2007*

From: A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials

Journal RCTs Reporting DMC or Interim/Total RCTs RCTs Reporting Early Termination/Total RCTs
General Journals   
   BMJ 3/62 (5%) 1/62 (2%)
   JAMA 11/24 (46%) 1/24 (4%)
   Lancet 23/83 (28%) 9/83 (11%)
   N Engl J Med 31/80 (39%) 3/80 (4%)
   Total 68/249 (27%) 14/249 (6%)
Pediatric Journals   
   Arch Dis Child 2/37 (5%) 2/37 (5%)
   Arch Ped Adolesc Med 4/61 (7%) 2/61 (3%)
   J Pediatr 7/88 (8%) 3/88 (3%)
   Pediatrics 24/213 (11%) 11/213 (5%)
   Total 37/399 (9%) 18/399 (5%)
  1. *The denominator refers to the total number of pediatric trials for each journal during the studied time period, which was obtained using Medline's filters (publication type "randomized controlled trial" and age category "0-18 years").