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Table 1 Demographic and main clinical characteristics

From: Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis

  AB success
N = 251
AB failure
N = 32
OR (95% CI) or
p-value
Gestational age (weeks) - mean (SD) 31.7 (5.1) 28.8 (4.4) 0.0034
>36 weeks - n (%) 55 (21.9) 2 (6.3) 0.24 (0.06-1.03)
<28 weeks - n (%) 61 (24.3) 14 (43.8) 2.42 (1.14-5.16)
<26 weeks - n (%) 35 (13.9) 10 (31.3) 2.81 (1.23-6.42)
Birthweight (g) - mean (SD) 1913 (1086) 1350 (978) 0.0065
<1501 g - n (%) 122 (48.6) 23 (71.9) 2.70 (1.20-6.07)
<1001 g - n (%) 59 (23.5) 16 (50.0) 3.25 (1.53-6.90)
<751 g - n (%) 23 (9.2) 11 (34.4) 5.19 (2.23-12.10)
M/F sex - n 143/108 20/12 1.26 (0.59-2.69)
Apgar score at 1 min - mean (SD) 5.3 (2.1) 4.3 (1.9) 0.0114
Apgar score at 5 min - mean (SD) 6.5 (1.5) 5.9 (1.5) 0.0422
Ventilated - n (%) 187 (74.5) 28 (87.5) 2.40 (0.81-7.09)
Surfactant - n (%) 141 (56.2) 28 (87.5) 5.46 (1.86-16.03)
Cesarean section - n (%) 142 (56.6) 15 (46.9) 0.68 (0.32-1.42)
Multiple pregnancies - n (%) 50 (19.9) 7 (21.9) 1.13 (0.46-2.75)
Chorioamnionitis - n (%) 40 (15.9) 11 (34.4) 2.76 (1.24-6.17)
PROM >18 h - n (%) 46 (18.3) 7 (21.9) 1.25 (0.51-3.06)
Prenatal glycocorticoids (full course) - n (%) 106 (42.2) 8 (25.0) 0.46 (0.20-1.05)
AB therapy during pregnancy 61 (24.3) 4 (12.5) 0.45 (0.15-1.32)
AB therapy during delivery 91 (36.3) 6 (18.8) 0.41 (0.16-1.02)
Proven EOS - n (%) 4 (1.6) 10 (31.3) 28.07 (8.13-96.88)
Early neonatal mortality - n (%) 10 (4.0) 14 (43.8) 18.74 (7.31-48.10)
  1. OR - odds ratio; 95% CI - 95% confidence interval; PROM - premature rupture of membranes; EOS - early onset neonatal sepsis; AB - antibiotic