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Table 1 Demographic and main clinical characteristics

From: Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis

 

AB success

N = 251

AB failure

N = 32

OR (95% CI) or

p-value

Gestational age (weeks) - mean (SD)

31.7 (5.1)

28.8 (4.4)

0.0034

>36 weeks - n (%)

55 (21.9)

2 (6.3)

0.24 (0.06-1.03)

<28 weeks - n (%)

61 (24.3)

14 (43.8)

2.42 (1.14-5.16)

<26 weeks - n (%)

35 (13.9)

10 (31.3)

2.81 (1.23-6.42)

Birthweight (g) - mean (SD)

1913 (1086)

1350 (978)

0.0065

<1501 g - n (%)

122 (48.6)

23 (71.9)

2.70 (1.20-6.07)

<1001 g - n (%)

59 (23.5)

16 (50.0)

3.25 (1.53-6.90)

<751 g - n (%)

23 (9.2)

11 (34.4)

5.19 (2.23-12.10)

M/F sex - n

143/108

20/12

1.26 (0.59-2.69)

Apgar score at 1 min - mean (SD)

5.3 (2.1)

4.3 (1.9)

0.0114

Apgar score at 5 min - mean (SD)

6.5 (1.5)

5.9 (1.5)

0.0422

Ventilated - n (%)

187 (74.5)

28 (87.5)

2.40 (0.81-7.09)

Surfactant - n (%)

141 (56.2)

28 (87.5)

5.46 (1.86-16.03)

Cesarean section - n (%)

142 (56.6)

15 (46.9)

0.68 (0.32-1.42)

Multiple pregnancies - n (%)

50 (19.9)

7 (21.9)

1.13 (0.46-2.75)

Chorioamnionitis - n (%)

40 (15.9)

11 (34.4)

2.76 (1.24-6.17)

PROM >18 h - n (%)

46 (18.3)

7 (21.9)

1.25 (0.51-3.06)

Prenatal glycocorticoids (full course) - n (%)

106 (42.2)

8 (25.0)

0.46 (0.20-1.05)

AB therapy during pregnancy

61 (24.3)

4 (12.5)

0.45 (0.15-1.32)

AB therapy during delivery

91 (36.3)

6 (18.8)

0.41 (0.16-1.02)

Proven EOS - n (%)

4 (1.6)

10 (31.3)

28.07 (8.13-96.88)

Early neonatal mortality - n (%)

10 (4.0)

14 (43.8)

18.74 (7.31-48.10)

  1. OR - odds ratio; 95% CI - 95% confidence interval; PROM - premature rupture of membranes; EOS - early onset neonatal sepsis; AB - antibiotic