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Table 5 Comparison of HIV-infected women with CD4+ cell counts 200–349/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

  HIV (+) CD4 200–349/μL HIV (-)  
Laboratory measures Mean N P2.75 P97.5 Mean N P2.75 P97.5 P value
Study visit at 20–24 weeks gestation
Red blood cells 106/μL 3.5 608 2.53 4.52 3.8 367 2.65 4.92 < .0001
Hemoglobin g/dL 10.0 607 6.7 12.2 11.0 367 8.2 13.2 < .0001
Hematocrit % 29.5 608 21 36.4 32.3 367 23.8 39.4 < .0001
Platelets 103/μL 231.9 608 101 413 204.3 367 97 350 < .0001
White blood cells 103/μL 5.7 608 2.6 9.1 6.9 366 3.3 11.1 < .0001
Lymphocytes % 30.4 597 16.4 58.1 31.5 358 19 57 0.0778
Monocytes % 8.4 597 2.1 21.4 6.8 358 1.9 17 < .0001
Granulocytes % 60.8 597 21.1 78.7 61.7 358 28.6 77.5 0.3
CD4 cells/μL 272.8 612 202 346 809.6 246 344 1366 < .0001
CD8 cells/μL 737.0 612 284 1589 513.5 246 262 1002 < .0001
CD4 % 22.7 92 12 37 47.6 55 33 65 < .0001
CD8 % 57.3 92 31 82 31.7 55 18 50 < .0001
Total T-Lymphocytes as % of all lymphocytes 76.4 75 48 98 75.6 47 60 93 0.7
Study visit at 36 weeks gestation
Red blood cells 106/μL 3.7 391 2.75 4.87 3.9 280 2.865 5.34 < .0001
Hemoglobin g/dL 10.5 391 7.9 13 11.3 280 9 13.95 < .0001
Hematocrit % 31.1 391 22.4 38.5 33.3 280 25.9 41.85 < .0001
Platelets 103/μL 201.6 391 88 356 182.9 280 86.5 344.5 0.0005
White blood cells 103/μL 5.6 391 3.3 8.9 6.7 280 3.8 11.2 < .0001
Lymphocytes % 30.8 387 16.2 50.7 31.8 274 18.1 53.6 0.1
Monocytes % 8.8 387 2.4 22.5 7.5 274 1.1 23.1 0.0020
Granulocytes % 60.2 387 30.4 78.5 60.7 274 32.6 76.5 0.6
CD4+ cells/μL 274.8 395 202 346 786.0 166 368 1325 < .0001
CD8+ cells/μL 757.2 395 313 1731 506.8 166 216 1106 < .0001
CD4 % 24.3 66 13 42 45.0 49 28 66 < .0001
CD8 % 54.1 66 32 73 31.1 49 21 43 < .0001
Total T-Lymphocytes as % of all lymphocytes 78.0 63 61 91 74.1 43 54 90 0.02
  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile