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Table 5 Comparison of HIV-infected women with CD4+ cell counts 200–349/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

 

HIV (+) CD4 200–349/μL

HIV (-)

 

Laboratory measures

Mean

N

P2.75

P97.5

Mean

N

P2.75

P97.5

P value

Study visit at 20–24 weeks gestation

Red blood cells 106/μL

3.5

608

2.53

4.52

3.8

367

2.65

4.92

< .0001

Hemoglobin g/dL

10.0

607

6.7

12.2

11.0

367

8.2

13.2

< .0001

Hematocrit %

29.5

608

21

36.4

32.3

367

23.8

39.4

< .0001

Platelets 103/μL

231.9

608

101

413

204.3

367

97

350

< .0001

White blood cells 103/μL

5.7

608

2.6

9.1

6.9

366

3.3

11.1

< .0001

Lymphocytes %

30.4

597

16.4

58.1

31.5

358

19

57

0.0778

Monocytes %

8.4

597

2.1

21.4

6.8

358

1.9

17

< .0001

Granulocytes %

60.8

597

21.1

78.7

61.7

358

28.6

77.5

0.3

CD4 cells/μL

272.8

612

202

346

809.6

246

344

1366

< .0001

CD8 cells/μL

737.0

612

284

1589

513.5

246

262

1002

< .0001

CD4 %

22.7

92

12

37

47.6

55

33

65

< .0001

CD8 %

57.3

92

31

82

31.7

55

18

50

< .0001

Total T-Lymphocytes as % of all lymphocytes

76.4

75

48

98

75.6

47

60

93

0.7

Study visit at 36 weeks gestation

Red blood cells 106/μL

3.7

391

2.75

4.87

3.9

280

2.865

5.34

< .0001

Hemoglobin g/dL

10.5

391

7.9

13

11.3

280

9

13.95

< .0001

Hematocrit %

31.1

391

22.4

38.5

33.3

280

25.9

41.85

< .0001

Platelets 103/μL

201.6

391

88

356

182.9

280

86.5

344.5

0.0005

White blood cells 103/μL

5.6

391

3.3

8.9

6.7

280

3.8

11.2

< .0001

Lymphocytes %

30.8

387

16.2

50.7

31.8

274

18.1

53.6

0.1

Monocytes %

8.8

387

2.4

22.5

7.5

274

1.1

23.1

0.0020

Granulocytes %

60.2

387

30.4

78.5

60.7

274

32.6

76.5

0.6

CD4+ cells/μL

274.8

395

202

346

786.0

166

368

1325

< .0001

CD8+ cells/μL

757.2

395

313

1731

506.8

166

216

1106

< .0001

CD4 %

24.3

66

13

42

45.0

49

28

66

< .0001

CD8 %

54.1

66

32

73

31.1

49

21

43

< .0001

Total T-Lymphocytes as % of all lymphocytes

78.0

63

61

91

74.1

43

54

90

0.02

  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile
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