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Table 4 Comparison of HIV-infected women with CD4+ cell counts <200/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

  HIV (+) CD4 < 200/μL HIV (-)  
Laboratory measures Mean N P2.75 P97.5 Mean N P2.75 P97.5 P value
  Study visit at 20–24 weeks gestation  
Red blood cells 106/μL 3.4 448 2.4 4.6 3.8 367 2.9 4.9 < .0001
Hemoglobin g/dL 9.6 447 7.0 12.0 11.0 367 8.2 13.2 < .0001
Hematocrit % 28.5 447 21.3 35.9 32.3 367 23.8 39.4 < .0001
Platelets 103/μL 226.0 449 100 391 204.3 367 97 350 < .0001
White blood cells 103/μL 5.2 449 2.7 9 6.9 366 3.3 11.1 < .0001
Lymphocytes % 28.0 435 12.8 55.1 31.5 358 19 57 < .0001
Monocytes % 8.9 435 2.4 23.8 6.8 358 1.9 17 < .0001
Granulocytes % 63.0 436 24 81.8 61.7 358 28.6 77.5 0.1
CD4+ cells/μL 130 456 26 198 809.6 246 344 1366 < .0001
CD8+ cells/μL 661 456 192 1615 513.5 246 262 1002 < .0001
CD4 % 14.0 89 3 29 47.6 55 33 65 < .0001
CD8 % 59.7 89 15 88 31.7 55 18 50 < .0001
Total T-Lymphocytes as % of all lymphocytes 69.6 76 17 92 75.6 47 60 93 0.04
  Study visit at 36 weeks gestation  
Red blood cells 106/μL 3.7 279 2.6 4.9 3.9 280 2.9 5.3 < .0001
Hemoglobin g/dL 10.4 279 7.4 13.2 11.3 280 9.0 14.0 < .0001
Hematocrit % 30.8 279 22.6 39.0 33.3 280 25.9 41.9 < .0001
Platelets 103/μL 208.8 279 77 419 182.9 280 87 345 < .0001
White blood cells 103/μL 5.0 279 2.4 8.5 6.7 280 3.8 11.2 < .0001
Lymphocytes % 28.7 279 13.5 51.6 31.8 274 18.1 53.6 < .0001
Monocytes % 8.8 279 2.6 21.9 7.5 274 1.1 23.1 0.003
Granulocytes % 62.5 279 35.6 80.4 60.7 274 32.6 76.5 0.06
CD4+ cells/μL 131 280 19 196 786 166 368 1325 < .0001
CD8+ cells/μL 656 280 215 1524 507 166 216 1106 < .0001
CD4 % 13.8 49 3 29 45.0 49 28 66 < .0001
CD8 % 60.2 49 34 88 31.1 49 21 43 < .0001
Total T-Lymphocytes as % of all lymphocytes 74.9 47 50 93 74.1 43 54 90 0.7
  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile