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Table 4 Comparison of HIV-infected women with CD4+ cell counts <200/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

 

HIV (+) CD4 < 200/μL

HIV (-)

 

Laboratory measures

Mean

N

P2.75

P97.5

Mean

N

P2.75

P97.5

P value

 

Study visit at 20–24 weeks gestation

 

Red blood cells 106/μL

3.4

448

2.4

4.6

3.8

367

2.9

4.9

< .0001

Hemoglobin g/dL

9.6

447

7.0

12.0

11.0

367

8.2

13.2

< .0001

Hematocrit %

28.5

447

21.3

35.9

32.3

367

23.8

39.4

< .0001

Platelets 103/μL

226.0

449

100

391

204.3

367

97

350

< .0001

White blood cells 103/μL

5.2

449

2.7

9

6.9

366

3.3

11.1

< .0001

Lymphocytes %

28.0

435

12.8

55.1

31.5

358

19

57

< .0001

Monocytes %

8.9

435

2.4

23.8

6.8

358

1.9

17

< .0001

Granulocytes %

63.0

436

24

81.8

61.7

358

28.6

77.5

0.1

CD4+ cells/μL

130

456

26

198

809.6

246

344

1366

< .0001

CD8+ cells/μL

661

456

192

1615

513.5

246

262

1002

< .0001

CD4 %

14.0

89

3

29

47.6

55

33

65

< .0001

CD8 %

59.7

89

15

88

31.7

55

18

50

< .0001

Total T-Lymphocytes as % of all lymphocytes

69.6

76

17

92

75.6

47

60

93

0.04

 

Study visit at 36 weeks gestation

 

Red blood cells 106/μL

3.7

279

2.6

4.9

3.9

280

2.9

5.3

< .0001

Hemoglobin g/dL

10.4

279

7.4

13.2

11.3

280

9.0

14.0

< .0001

Hematocrit %

30.8

279

22.6

39.0

33.3

280

25.9

41.9

< .0001

Platelets 103/μL

208.8

279

77

419

182.9

280

87

345

< .0001

White blood cells 103/μL

5.0

279

2.4

8.5

6.7

280

3.8

11.2

< .0001

Lymphocytes %

28.7

279

13.5

51.6

31.8

274

18.1

53.6

< .0001

Monocytes %

8.8

279

2.6

21.9

7.5

274

1.1

23.1

0.003

Granulocytes %

62.5

279

35.6

80.4

60.7

274

32.6

76.5

0.06

CD4+ cells/μL

131

280

19

196

786

166

368

1325

< .0001

CD8+ cells/μL

656

280

215

1524

507

166

216

1106

< .0001

CD4 %

13.8

49

3

29

45.0

49

28

66

< .0001

CD8 %

60.2

49

34

88

31.1

49

21

43

< .0001

Total T-Lymphocytes as % of all lymphocytes

74.9

47

50

93

74.1

43

54

90

0.7

  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile
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