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Table 5 Multivariate analysis of the association between factors recorded in birth records and acute lymphoblastic leukemia.*+

From: Parental and infant characteristics and childhood leukemia in Minnesota

  Sub-cohort Cases   
  No. (%) No. (%) HR 95% CI
Maternal age (continuous/5 year increase) 7230 481 0.97 0.88–1.08
Maternal Ethnicity     
   black 280 (4) 8 (2) 0.43 0.21–0.88
   other/unknown 340 (5) 21 (4) 0.95 0.59–1.51
   white 6610 (91) 452 (94)   ref.
Maternal Education     
   high school 2651 (37) 160 (33)   ref.
   <high school 740 (10) 46 (10) 1.11 0.77–1.58
   >high school 3839 (53) 275 (57) 1.18 0.95–1.47
Last live birth interval     
   no live births 2915 (40) 183 (38)   ref.
   <3 years 2783 (38) 172 (36) 1.00 0.80–1.25
   ≥3 years 1532 (21) 126 (26) 1.36 1.05–1.76
Child gender     
   female 3514 (49) 187 (39)   ref.
   male 3716 (51) 294 (61) 1.43 1.18–1.74
Birth weight percentile     
   < 5th (< 2495 g) 320 (4) 25 (5) 1.37 0.80–2.34
   5th-25th (2496–3117 g) 1436 (20) 71 (15)   ref.
   26th-50th (3118–3458 g) 1811 (25) 105 (22) 1.17 0.85–1.60
   51st-75th (3459–3798 g) 1797 (25) 130 (27) 1.37 1.00–1.86
   76th-95th (3799–4309 g) 1510 (21) 115 (24) 1.40 1.02–1.92
   ≥95th (≥ 4309 g) 356 (5) 35 (7) 1.71 1.11–2.65
One minute Apgar score     
   0–7 1681 (23) 138 (29) 1.30 1.05–1.61
   >7 5549 (77) 343 (71)   ref.
  1. *All variables are mutually adjusted for each other, gestational age, and birth year.
  2. +Excludes 1599 individuals with missing data or who were born prior to 1980 (the earliest year gestational age was recorded in birth records).