Table 3 Predictive values of GHD predictors.
Clinical decision rule*** | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Growth rate < -1 SD | BMI ≥ 0 z-score | IGF-I < -2 SD | Construction† | Validation‡ | |||||
GHD | All | Certain | All | Certain | All | Certain | All | Certain | |
Sensitivity | 77 [60–90] | 100 [48–100] | 47 [31–63] | 60 [15–95] | 78 [64–91] | 100 [48–100] | 63 [47–79] | 100 [48–100] | 92 [76–100] |
Specificity | 50 [41–58] | Idem | 76 [69–83] | Idem | 37 [29–46] | Idem | 68 [60–76] | Idem | 70 [53–88] |
PPV* | 30 [20–39] | 7 [2–16] | 35 [22–48] | 9 [2–24] | 25 [17–34] | 6 [2–13] | 35 [23–47] | 11 [2–20] | Not applicable |
NPV** | 89 [79–95] | 100 [94–100] | 84 [77–91] | 98 [95–100] | 86 [77–95] | 100 [93–100] | 87 [80–94] | 100 [92–100] | Not applicable |