Selecting short-statured children needing growth hormone testing: Derivation and validation of a clinical decision rule

Table 2 Relations between potential predictors and GHD, before and after adjustment.

Variables	Absence of GHD (n = 131)		GHD (n = 36)		OR	CI	p	AOR*	CI*	pAOR*
	n	%	n	%
History and physical examination
Boys	62	47	20	56	1.4	0.7–2.9	0.4
Girls	69	53	16	44
Age < 5 years	29	22	10	28	1.4	0.6–3.1	0.5
Age ≥ 5 years	102	78	26	72
Height < -2.5 SD	48	37	16	44	1.4	0.7–2.9	0.4
Height ≥ -2.5 SD	83	63	20	56
Weight ≥ -2 SD	21	16	8	22	1.5	0.6–3.8	0.4
Weight < -2 SD	110	84	28	78
Growth rate < -1 SD	64	50	27	77	3.3	1.4–8.1	0.005	3.2	1.3–7.9	0.01
Growth rate ≥ -1 DS	63	50	8	23
Difference between height and MTH ≤ -3 SD	15	12	5	15	1.3	0.4–4.0	0.6
Difference between height and MTH > -3 SD	112	88	28	85
BMI ≥ 0 z-score	31	24	17	47	2.9	1.3–6.4	0.006	2.8	1.2–6.5	0.01
BMI < 0 z-score	100	76	19	53
Pre-pubertal children (Tanner = 1)	104	79	33	92	2.9	0.8–10	0.09	**
Pubertal children (Tanner > 1)	27	21	3	8
Studies
IGF-I < -2 SD	82	63	28	78	2.1	0.9–5.0	0.09	2.8	1.1–7.3	0.04
IGF-I ≥ -2 SD	49	37	8	22
Bone age delay ≥ 1.5 years	88	70	27	79	1.6	0.6–4.1	0.3
Bone age delay < 1.5 years	37	30	7	21

ISSN: 1471-2431