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Table 3 Quality assessment of included trials

From: A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy – are we there yet?

Included Trial Gunn 1998 Gluckman 2005 Shankaran 2002 Shankaran 2005 Eicher 2005
Adequacy of method of randomisation Yes
Computer
generated
Yes
Computer
generated, block
Yes
Computer
generated, block
Yes
Computer
generated, block
Yes
Central
website, block
Concealment of allocation Yes
Sealed opaque
envelopes
Yes
Sealed opaque
envelopes
Yes
Central data- coordinating center
Yes
Central data- coordinating center
Yes
Central website
Blinding of intervention None
Due to nature of intervention
None
Due to nature of intervention
None
Due to nature of intervention
None
Due to nature of intervention
None Due to nature of intervention
Blinding of outcome assessors Not robustly Yes No Yes Unknown
Completeness of follow-up Yes (96%) Yes (93%) Follow-up not reported# Yes (98%) No (68%)#
  1. # Data from this trial was only pooled for analysis of mortality and adverse events