Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report

Table 2 Summary of TSI administration, pulmonary function, and hematologic profiles at 5 years and after

	Off TSI	Intravenous tobramycin ~1 week	~1 weeks post intravenous tobramycin	Off TSI	On TSI 300 mg/5 mL twice daily	Off TSI	Off TSI
Age	5 years	5 1/2 years	5 1/2 years	6 years	6 1/2 years	7 years	7 1/2 years
Pulmonary Function	FVC 105% FEV₁ 90%	FVC 45% FEV₁ 27%	FVC 76% FEV₁ 64%	FVC 103% FEV₁ 93%	FVC 49 % FEV₁ 32 %	FVC 90% FEV₁ 81%	FVC 91% FEV₁ 78%
WBC (/mm ³ )	7.9	16	15.8	NA	17.7	13.5	9.9
Eosinophils (%)	2	13	1	NA	14	0	1
IgE (IU/mL)	123	165	NA	NA	205	306	166

Abbreviations: TSI, tobramycin solution for inhalation; WBC, white blood cell count; FVC, forced vital capacity; FEV₁, forced expiratory volume in 1 second; NA, not available

ISSN: 1471-2431