Table 1 Results of NPD measurements in CF patients, heterozygotes for 1 CF mutation and healthy controls.
Variables | CF (n = 37) | Htz (n = 37) | Ctrls (n = 29) | p CF vs. Htz | p CF vs. Ctrls | p Htz vs. Ctrls |
|---|---|---|---|---|---|---|
Baseline NPD(mV) | -47(2.6) | -15.5(1.3) | -15(1.5) | <0.0001 | <0.0001 | 0.9 |
Δamiloride (mV) | 24(2.2) | 6.2(0.9) | 7.1(1.2) | <0.0001 | <0.0001 | 0.69 |
Δchloride-free(mV) | 0.5(1.1) | -6(0.8) | -10.1(1.5) | <0.0001 | <0.0001 | 0.01 |
Δisoproterenol (mV) | -1(0.3) | -2.5(0.3) | -5(0.6) | 0.004 | <0.0001 | 0.003 |
ΔCl-free-Isoproterenol (mV) | 1(1.3) | -8.2(0.9) | -15(1.7) | 0.008 | <0.0001 | 0.0002 |