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Table 1 History of the most severe diarrhea events caused by microbial infections of intestine of the MPS I patient

From: Atypical microbial infections of digestive tract may contribute to diarrhea in mucopolysaccharidosis patients: a MPS I case study

Age of the patienta Detected pathogenic microbial strain(s) Antimicrobial agent(s) used Special remarks
11 months E. coli (group C) Trimethoprim and sulphamethoxazole Severe diarrhea and vomiting, metabolic acidosis, hospitalization and i.v. rehydration required
21 months (1 y. 9 mo.) E. coli (group C) Cefuroxime Initially applied trimethoprim and sulphamethoxazole did not give a therapeutic effect
27 months (2 y. 3 mo.) E. coli (group A) Nifuroxazide None
28 months (2 y. 4 mo.) P. aeruginosa None Tablets containing Lactobacillus rhamnosus were used to normalize intestinal flora
29 months (2 y. 5 mo.) E. coli (group C) Furazidin None
45 months (3 y. 9 mo.) Adenoviruses, C. albicans (in addition, H. parainfluenzae, S. viridans and Neiserria sp. were isolated from oral cavity) Cefuroxime, fluconazole, trimethoprim and sulphamethoxazole Very severe diarrhea and vomiting, severe dehydration and electrolyte depletion, metabolic acidosis, severe stomatitis. Hospitalization and parenteral nutrition required
49 months (4 y. 1 mo.) Adenoviruses None None
50 months (4 y. 2 mo.) E. coli (group C) Furazidin, trimethoprim and sulphamethoxazole Severe diarrhea, hospitalization and i.v. rehydration required
54 months (4 y. 6 mo.) Adenoviruses None None
55 months (4 y. 7 mo.) E. coli (group C) Furazidin None
56 months (4 y. 8 mo.) E. coli (group C), S. aureus, C. albicans Furazidin, fluconazole None
  1. a Age of the patient is provided in months as well as in years (y.) and months (mo.) in parentheses