Association between congenital toxoplasmosis and parent-reported developmental outcomes, concerns, and impairments, in 3 year old children

Table 3 Factors associated with parental concerns, specialist referral, impact of behaviour on the family, and parental anxiety, at 3 years, adjusted for centre and congenital infection status(Total N = 705)

	Odds ratio for outcome (95% confidence interval)
EXPOSURES	Any concerns⁵	Any referral	Behaviour impact⁴	Parental anxiety³
*Before birth*
1) Congenital toxoplasmosis (reference = uninfected)	0.98 (0.95, 1.01)	2.00 (0.90, 4.45)	0.55 (0.22, 1.39)	3.01 (1.84, 4.94)
2) Maternal Age ¹	0.97 (0.92, 1.03)	0.96 (0.89, 1.05)	0.98 (0.90, 1.07)	0.98 (0.93, 1.03)
3) Parity ¹	0.96 (0.81, 1.15)	1.05 (0.72, 1.54)	0.98 (0.66, 1.44)	1.26 (1.06, 1.50)
4) Maternal Education ¹	0.91 (0.73, 1.14)	0.77 (0.51, 1.16)	1.18 (0.81, 1.74)	0.82 (0.65, 1.04)
5) Mother born outside country ² (no = reference)	1.59 (0.84, 3.01)	0.82 (0.18, 3.79)	2.20 (0.86, 5.60)	1.06 (0.51, 2.21)
6) Child's gender (male = reference)	1.89 (1.22, 2.93)	0.83 (0.39, 1.73)	0.99 (0.50, 1.96)	1.26 (0.81, 1.94)
7) Duration of prenatal treatment (wks)	0.98 (0.96, 1.00)	1.00 (0.96, 1.04)	1.01 (0.97, 1.05)	0.97 (0.94, 0.99)
After birth
8) Child's age at Questionnaire ¹ (month)	0.97 (0.90, 1.04)	1.07 (0.97, 1.19)	1.02 (0.93, 1.13)	0.97 (0.90, 1.04)

¹Odds ratio expresses risk of adverse developmental/behavioural outcome per unit increase in exposure, adjusted for centre and congenital infection status
²Odds ratio expresses risk of adverse developmental/behavioural outcome, adjusted for centre and congenital infection status
³Adverse outcome defined by score corresponding most closely to the least able/most worried 10% in the uninfected children
⁴Adverse outcome defined by developers of SDQ questionnaire.
⁵Defined by answering 'yes' or 'a little' to question(s) about concerns.

ISSN: 1471-2431