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Table 2 Factors associated with development and behaviour at 3 years, adjusted for centre and congenital infection status (Total N = 705)

From: Association between congenital toxoplasmosis and parent-reported developmental outcomes, concerns, and impairments, in 3 year old children

EXPOSURES

Infection status

 

Odds ratio for abnormal developmental outcome (95% confidence interval)

    

Parent completed

 

Child completed

Before birth

CT+

CT-

Motor

Speech & language

Behaviour

Cognition

'Draw a Man'

Line, circle, cross

1) Congenital toxoplasmosis (reference = uninfected)

178

525

1.35

(0.79, 2.30)

1.32

(0.75, 2.33)

1.10

(0.70, 1.73)

0.88

(0.37, 2.08)

0.94

(0.51, 1.74)

1.05

(0.53, 2.07)

2) Maternal age (yrs) 1*

<25

40

86

1.07

(1.02, 1.12)

0.93

(0.88, 0.99)

0.92

(0.87, 0.97)

0.97

(0.90, 1.05)

1.04

(0.99, 1.09)

1.00

(0.93, 1.07)

25–35

106

288

      

>35

27

35

      

3) Parity 1*

0

40

179

1.00

(0.80, 1.24)

1.18

(0.94, 1.48)

0.97

(0.74, 1.27)

1.22

(0.93, 1.60)

0.96

(0.70, 1.31)

1.02

(0.74, 1.40)

= 1

72

212

      

Missing

66

136

      

4) Maternal education 1

Primary

14

48

1.15

(0.89, 1.48)

0.58

(0.44, 0.77)

0.77

(0.63, 0.94)

0.74

(0.52, 1.05)

1.20

(0.87, 1.66)

1.01

(0.73, 1.38)

Secondary Lower

47

181

      

Secondary Upper

47

135

      

Further Education

66

152

      

Missing

4

11

      

5) Mother born outside country 2

Yes

25

60

1.45

(0.74, 2.84)

2.30

(1.14, 4.63)

1.65

(0.92, 2.96)

2.25

(0.88, 5.78)

0.89

(0.39, 2.01)

1.66

(0.72, 3.83)

no (reference)

152

462

      

Missing

1

5

      

6) Child's gender 2

Male (reference)

95

284

1.45

(0.74, 2.84)

0.81

(0.49, 1.36)

1.65

(0.92, 2.96)

2.25

(0.88, 5.78)

0.89

(0.39, 2.01)

1.66

(0.72, 3.83)

Female

83

232

      

Missing

0

11

      

7) Duration of prenatal treatment 1 (mean wks, sd)

6.3

(6.5)

15.1

(12.2)

1.00

(0.98, 1.02)

1.02

(0.99, 1.05)

1.00

(0.98, 1.02)

0.99

(0.96, 1.02)

0.98

(0.96, 1.01)

1.00

(0.98, 1.03)

Missing

0

0

      

Exposures after birth

8) Child's age at questionnaire 1 (months) Median, IQR

38

(37,40)

39

(38, 41)

0.81

(0.71, 0.93)

0.87

(0.77, 0.98)

0.98

(0.93, 1.04)

0.73

(0.56, 0.97)

0.88

(0.80, 0.97)

0.73

(0.60, 0.88)

Missing

0

1

      
  1. 1Odds ratio expresses risk of adverse developmental/behavioural outcome per unit increase in exposure, adjusted for centre and congenital infection status.
  2. 2Odds ratio expresses risk of adverse developmental/behavioural outcome, adjusted for centre and congenital infection status
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BMC Pediatrics

ISSN: 1471-2431

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