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Table 1 Initial developmental quotient in relation to various prenatal and perinatal risk factors

From: Predictors of severity and outcome of global developmental delay without definitive etiologic yield: a prospective observational study

  

N

DQ

P

Prenatal factors

    

Fecundation in vitro

yes

7

46 ± 12.1

0.124

 

no

135

52.5 ± 10.8

 

Drug exposure in pregnancy*

yes

14

51.2 ± 11.3

0.734

 

no

128

52.3 ± 11.5

 

Tobacco smoke exposure in pregnancy

yes

42

50.0 ± 11.4

0.127

 

no

100

53.1 ± 10.8

 

Multiple gestation

yes

12

44.1 ± 11.2

0.012

 

no

130

52.9 ± 11.4

 

Prematurity

yes

43

46.8 ± 11.6

<0.001

 

no

99

54.5 ± 11.0

 

Post-term birth

yes

11

50.1 ± 12.3

0.517

 

no

131

52.4 ± 11.2

 

IUGR

yes

32

42.8 ± 11.1

<0.001

 

no

110

54.9 ± 11.4

 

Hypertensive disease of pregnancy †

yes

9

44.2 ± 10.9

0.030

 

no

133

52.7 ± 11.3

 

Hemorrhagic complications of pregnancy ‡

yes

13

48.3 ± 11.6

0.180

 

no

129

52.6 ± 10.9

 

Perinatal factors

    

Cesarean section

yes

55

51.3 ± 11.3

0.445

 

no

87

52.8 ± 11.4

 

Birth asphyxia

yes

18

45.8 ± 12.0

0.012

 

no

124

53.1 ± 11.3

 

Neonatal hypoxia §

yes

40

48.4 ± 11.5

0.014

 

no

102

53.7 ± 11.4

 

Neonatal infection

yes

9

46.3 ± 12.2

0.109

 

no

133

52.6 ± 11.3

 
  1. Data are means ± SD.
  2. *exposure to alcohol and illicit drugs; † preeclampsia, eclampsia; ‡ placental abruption, placenta previa; § need for ventilatory support due to respiratory distress or severe apneas;
  3. DQ indicates developmental quotient; IUGR intrauterine growth restriction.