Table 1 First detection of specific autoantibodies compared to the age of onset of APS 1 components
Specific autoantibodies | Age at first test (years) | Age at first detection (years) | Related APS 1 component | Onset of APS 1 component (years) |
|---|---|---|---|---|
Anti-thyroglobulin | 5 | 5 | Autoimmune thyroiditis | 5 |
Anti-thyreoperoxidase | 5 | 5 | Autoimmune thyroiditis | 5 |
Anti-parietal cells | 7 | 7 | Autoimmune gastritis | - |
Anti-adrenal cortex | 7 | 7 | Addison disease | 11 |
Anti-21-hydroxylase | 8 | 8 | Addison disease | 11 |
Anti-17alpha hydroxylase | 8 | 8 | Addison disease | 11 |
Ovarian failure | 12 | |||
Anti-P450 side chain cleavage | 8 | 8 | Addison disease | 11 |
Ovarian failure | 12 | |||
Anti-steroid-producing cells | 8 | 8 | Ovarian failure | 12 |
Anti-tryptophan hydroxylase | 9 | 10 | Autoimmune hepatitis | - |
Autoimmune enteropathy | 5 | |||
Anti-L-aminoacid decarboxylase | 9 | 10 | Vitiligo | 9 |
Autoimmune hepatitis | - |