Table 3 Neonatal data and routine laboratory at the first day of life according to the VKORC1 -genotype (median with range and percentages, respectively)
VKORC1-1639G>A wildtype (GG) (n = 34) | VKORC1-1639G>A carrier (GA + AA) (n = 40 + 13) | p-value | |
|---|---|---|---|
Gestational age | 28 + 6 (24 + 0 – 31 + 5) | 27 + 4 (23 + 3 – 31 + 1) | 0.057 |
Birth weight [g] | 1037.5 (410 – 2005) | 915 (320 – 2270) | 0.095 |
Male [%] | 67.6 | 69.8 | 1.000 |
IVH [%] | 26.5 | 13.2 | 0.158/*0.019 |
Prenatal steroids [%] | 64.7 | 69.2 | 0.814 |
Surfactant [%] | 82.4 | 83.0 | 1.000 |
CPAP [%] | 94.1 | 86.8 | 0.473 |
Intubation [%] | 44.1 | 39.6 | 0.824 |
PDA medicament [%] | 79.2 | 76.5 | 0.795 |
PDA OP [%] | 5.9 | 5.7 | 1.000 |
Sepsis [%] | 11.8 | 7.5 | 0.706 |
Apgar 5 min | 8 (2 – 9) | 8 (5 – 10) | 0.062 |
CRIB-Score | 2 (0 – 14) | 3.5 (0 – 16) | 0.166 |
Il-6 [pg/ml] | 35.0 (3.8 – 775.0) | 55.6 (2.0 – 57,050.0) | 0.388 |
CRP [mg/l] | 0.2 (0.2 – 51.1) | 0.2 (0.2 – 78.2) | 0.031/*0.271 |
Hematocrit [%] | 46 (10.7 – 59.0) | 44 (15.2 – 59.0) | 0.047/*0.268 |
Leucocytes [×103/μl] | 7.28 (1.98 – 32.00) | 7.30 (1.08 – 26.25) | 0.889 |
Thrombocytes [×103/μl] | 165 (29 – 235) | 160 (15 – 291) | 0.258 |
FII [activity in%] | 29.5 (20 – 53) | 33 (17 – 65) | 0.495/*0.154 |
FVII [activity in%] | 30.5 (13 – 93) | 31 (7 – 69) | 0.868/*0.330 |
FX [activity in%] | 37.5 (24 – 73) | 44 (14 – 89) | 0.682/*0.235 |
ATIII [activity in%] | 29 (13 – 51) | 29.5 (13 – 48) | 0.903/*0.532 |