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Table 1 Neonatal data and routine laboratory at the first day of life according to the diagnosis of IVH confirmed by ultrasound at the 7 th day of life (median with range and percentages, respectively)

From: Genetic variants of the vitamin K dependent coagulation system and intraventricular hemorrhage in preterm infants

 

Total (n = 90)

Non-IVH (n = 73)

IVH (n = 17)

p-value

Gestational age [weeks + days]

28 + 0 (23 + 3 -31 + 5)

28 + 3 (24 + 0 - 31 + 5)

27 + 0 (23 + 3 - 30 + 2)

0.016

Birth weight [g]

990 (320 – 2270)

990 (400 – 2270)

920 (320 – 1495)

0.248

Male [%]

67.8

67.1

70.6

1.000

SGA [%]

18.9

19.2

17.6

0.727

Prenatal steroids [%]

67.4

68.1

64.7

0.781

AIS [%]

5.6

5.5

5.9

1.000

Cesarean section [%]

98.9

98.6

100

1.000

Surfactant [%]

83.3

79.5

100

0.065

RDS [%]

85.6

84.9

88.2

1.000

RDS [median grade]

2

2

2

0.549

CPAP [%]

88.9

93.2

70.6

0.019

Intubation [%]

41.1

34.2

70.6

0.012

PDA [%]

75.6

71.2

94.1

0.061

PDA medicament [%]

78.9

75.3

94.1

0.108

PDA OP [%]

5.6

2.7

17.6

0.045

Sepsis [%]

10.0

6.8

23.5

0.061

Catecholamines [%]

42.2

38.4

58.8

0.173

umbilical artery pH

7.33 (7.15 - 7.52)

7.33 (7.15 - 7.52)

7.34 (7.22 - 7.38)

0.530

Apgar 5 min

8 (2–10)

8 (2–10)

8 (6–9)

0.183

CRIB-Score

2.5 (0–16)

2.0 (0–14)

5.0 (1–16)

0.495

Mean arterial pressure [mmHg]

33.5 (19–60)

34.0 (20–60)

27 (19–42)

0.053

Hematocrit [%]

45.0 (10.7 - 59.0)

47.0 (10.7 - 59.0)

41.0 (24.0 - 59.0)

0.075

Leucocytes [×103/μl]

7.24 (1.08 - 32.00)

7.39 (1.08 - 32.00)

6.63 (1.16 - 26.25)

0.613

Thrombocytes [×103/μl]

160 (15–291)

150 (15–272)

175 (30–291)

0.270

Il-6 [pg/ml]

51.6 (2.0 - 689,002.0)

42.3 (2.0 - 57,050.0)

92.1 (12.9 - 689,002.0)

0.197

CRP [mg/l]

0.2 (0.2 - 78.2)

0.2 (0.2 - 78.2)

0.2 (0.2 – 20.9)

0.461

FII [activity in%]

32 (17–65)

35 (17–65)

27 (18–36)

0.001/*0.006

FVII [activity in%]

31 (7–93)

31,5 (7–93)

29 (10–48)

0.116/*0.281

FX [activity in%]

41 (14–89)

46 (14–89)

33 (24–62)

0.007/*0.023

ATIII [activity in%]

30 (13–51)

30.0 (13–51)

28 (13–45)

0.241/*0.383

  1. *adjusted for gestational age.
  2. Definitions: Antenatal steroids: maternal Betamethason treatment 2x 12 mg (i.v.) > 24 prior delivery; AIS: Chorioamnionitis: clinical diagnosis of chorioamnitis (maternal temperature > 38° Celsius, leucocytosis > 15,0000, CRP > 20 mg/l); SGA: birth weight < 3rd centile; Catecholamine treatment (n = 130): any catecholamine treatment (Dopamine, Dobutamine, Epinephrine) to maintain blood pressure > 10th centile < 72 hours postnatal age.
  3. Bold numbers are used for results reaching statistical significance.