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Table 7 Univariate and multivariate analyses of risk factors for suppurative OM, adjusted for community

From: Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules

  With suppurative OM** UNI-VARIATE OR 95% CI p MULTI-VARIATE OR 95% CI P*
Vaccine group        
PCV7 51%       
PHiD-CV10 39% 0.64 0.48 to 0.86 0.003 0.58 0.41 to 0.80 0.001
Children under age of 5 years in household        
0 39%    0.003    0.009
1 47% 1.43 0.98 to 2.10   1.34 0.91 to 1.98  
2 53% 1.85 1.12 to 3.07   1.66 0.99 to 2.80  
3+ 60% 2.42 1.46 to 3.99   2.36 1.41 to 4.00  
Age group (years)        
< 1 year 58%    0.000    0.000
1 to < 2 years 47% 0.70 0.49 to 1.0   0.72 0.50 to 1.04  
2 to < 3 years 30% 0.33 0.22 to 0.49   0.31 0.20 to 0.47  
Gender        
Male 41%       
Female 49% 1.41 1.07 to 1.86 0.016 1.46 1.07 to 1.92 0.016
Antibiotics prescribed in previous 5 weeks        
None 44%       
Any 47% 1.21 0.90 to 1.62 0.20 1.24 0.91 to 1.69 0.17
Haemoglobin        
> = 11 mg/dL 42%       
<11 mg/dL 49% 1.28 0.93 to 1.75 0.13    
Child care attendance        
none 47%       
any 47% 1.03 0.64 to 1.67 0.91    
Sibling history of OM “runny ears’        
No 47%       
Yes 47% 0.98 0.69 to 1.39 0.90    
Maternal smoking        
No 46%       
Yes 48% 1.11 0.80 to 1.53 0.53    
Child near campfire last week        
No 48%       
Yes 47% 0.89 0.63 to 1.35 0.51    
Maternal age at birth of this child        
> = 21 yrs 43%       
< 21 yrs 52% 1.39 0.97 to 1.99 0.07    
Maternal education        
no certificate 46%       
certificate 49% 1.07 0.74 to 1.57 0.71    
Breastfed        
Never 51%       
Some 47% 0.86 0.45 to 1.65 0.65    
Pacifier        
Never 47%       
Some 47% 1.02 0.70 to 1.54 0.91    
Gestational age        
> = 32 weeks 45%       
< 32 weeks 54% 1.3 0.60 to 3.06 0.51    
  1. *Bold signifies P value less than 0.05.
  2. **Analysis of 383 children with and 465 children without suppurative OM.