Birth after preeclamptic pregnancies: association with allergic sensitization and allergic rhinoconjunctivitis in late childhood; a historically matched cohort study

Table 3 Summary of logistic regression analyses of atopic diseases in late childhood in 586 Norwegian children according to mother’s preeclampsia status

Effects of maternal preeclampsia
	Fully adjusted^a)						Final analysis^b)
	n	Mild/moderate preeclampsia		Severe preeclampsia		Likelihood-ratio-	n	Mild/moderate preeclampsia		Severe preeclampsia		Likelihood-ratio
Outcome variable		OR	95% CI	OR	95% CI	p		OR	95% CI	OR	95% CI	p
FU1 variables
Allergic rhinoconjunctivitis	514	1.21	(0.70, 2.07)	2.10	(0.86, 5.11)	0.268	586	1.25	(0.79, 1.97)	2.23	(1.20, 4.17)	0.046
Atopic dermatitis	513	0.90	(0.54, 1.50)	0.97	(0.39, 2.39)	0.914						____
Asthma	506	0.87	(0.38, 1.97)	0.72	(0.19, 2.77)	0.878						____
FU2 variables
Allergic sensitization	329	1.49	(0.84, 2.63)	2.44	(0.93, 6.42)	0.138						____
High level allergic sensitization^c)	329	1.64	(0.87, 3.11)	4.42	(1.58, 12.3)	0.015	347	1.60	(0.88, 2.91)	4.05	(1.62, 10.1)	0.010^d)
Current asthma	388	1.11	(0.45, 2.73)	0.69	(0.15, 3.18)	0.802						____

Abbreviations: OR Odds ratio, CI Confidence interval, FU1 first follow-up at the ages of 10.8 years (girls) and 11.8 years (boys), FU2 second follow-up at the age of 12.8 years (both genders); Likelihood-ratio-p refers to exposure only.
^a)Adjusted for gender, birth weight z-score adjusted for gestational age, being firstborn, Caesarean section, maternal smoking during pregnancy, gestational age in weeks, maternal age, maternal body mass index (kg/m²) and maternal asthma;
^b)After backward stepwise selection from fully adjusted model with p ≤ 0.05; all final analyses include the covariates gender and maternal asthma as default.
^c)High level allergic sensitization = Sum of specific IgE > 3.9 kU/l; the 25 percentile of sensitized children.
^d)Adjusted for gender, maternal smoking during pregnancy, gestational age in weeks and maternal asthma. No significant interaction effects were found in final analyses.

ISSN: 1471-2431