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Table 3 Drugs identified as manipulated using British National Formulary for Children (BNFC) classification [19]

From: Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence

BNFC classification

Number of manipulations identified – observational study (percentage)

Number of manipulations identified – questionnaire (percentage)

Analgesic

92 (29.7%)

33 (17.6%)

Proton pump inhibitor

24 (7.7%)

24 (12.8%)

Antimuscarinic

18 (5.4%)

20 (10.6%)

Antiemetic

17 (5.5%)

5 (2.7%)

Alginate preparation

16 (5.2%)

2 (1.1%)

Antiplatelet

15 (4.8%)

3 (1.6%)

Opioid analgesic

14 (4.5%)

2 (1.1%)

Benzodiazepines

13 (4.2%)

2 (1.1%)

Antiepileptic

12 (3.9%)

6 (3.2%)

Antibiotic

11 (3.5%)

7 (3.7%)

Neuromuscular blocking

11 (3.5%)

0

Steroid

10 (3.2%)

12 (6.4%)

ACE inhibitor

5 (1.6%)

2 (1.1%)

Bronchodilator

5 (1.6%)

23 (12.2%)

Minerals

5 (1.6%)

2 (1.1%)

Thyroid hormone

5 (1.6%)

1 (0.5%)

Vasodilator

5 (1.6%)

1 (0.5%)

Diuretic

4 (1.3%)

0

Drugs affecting the ductus arteriosus

3 (1.0%)

0

Insulin

3 (1.0%)

0

Laxative

3 (1.0%)

4 (2.1%)

Antipsychotic

2 (0.6%)

1 (0.5%)

Antiviral

2 (0.6%)

1 (0.5%)

Flu prophylaxis

2 (0.6%)

0

Hypothalamic & pituitary hormone

2 (0.6%)

0

H2 antagonist

2 (0.6%)

8 (4.3%)

Inotrope

2 (0.6%)

0

Anticoagulant

1 (0.3%)

2 (1.1%)

Antidepressant

1 (0.3%)

0

Antihypertensive

1 (0.3%)

1 (0.5%)

Antimotility

1 (0.3%)

3 (1.6%)

Pineal hormone

1 (0.3%)

2 (1.1%)

Smooth muscle relaxant

1 (0.3%)

0

Osmotic laxative

0

6 (3.2%)

Immunosuppressant

0

4 (2.1%)

Sedation

0

3 (1.6%)

Calcium channel blocker

0

2 (1.1%)

Cytotoxic

0

2 (1.1%)

Vitamin

0

2 (1.1%)

Beta-blocker

0

1 (0.5%)

Skeletal muscle relaxant

0

1 (0.5%)

Not in BNFC

1 (0.3%)

0

Total

310 (100%)

188 (100%)