Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours

Table 7 Prediction of moderate-severe HIE presenting in the first 72 hours after birth

Encephalopathy assessment	n		moderate-severe HIE n (%)	Sensitivity (95%CI)	Specificity (95%CI)	LR + (95%CI)	LR - (95%CI)	LR Test (Odds ratio) (95%CI)
aEEG abnormal age 6 hours	Yes	36	36 (100)	75%	100%	19.4 ^a	0.27 ^a	73 ^a
aEEG abnormal age 6 hours	No	24	12 (50)	(60 – 86)	(74 – 100)	(1.3 – 294.9)	(0.16 – 0.43)	(4 – 1325)
Moderate-severe encephalopathy age 3 – 5 hours	Yes	42	42 (100)	88%	100%	23 ^a	0.1 ^a	163.5 ^a
Moderate-severe encephalopathy age 3 – 5 hours	No	18	6 (33)	(75 – 95)	(74 – 100)	(1.5 – 342.4)	(0.1 – 0.3)	(8.6 – 3106.8)
Thompson score ≥ 7 age 3 – 5 hours	Yes	44	43 (98)	90%	92%	7.7 ^a	0.1 ^a	60.6 ^a
Thompson score ≥ 7 age 3 – 5 hours	No	16	5 (31)	(77 – 97)	(62 – 100)	(1.7 – 34.8)	(0.1 – 0.3)	(8.9 – 413.1)
aEEG abnormal age 3 hours and/or 6 hours	Yes	40	39 (98)	81%	50%	1.6 ^a	0.4 ^a	4.2 ^a
	No	10	9 (90)	(67 – 91)	(1 – 99)	(0.5 – 5)	(0.1 – 1.4)	(0.4 – 44.5)

aEEG: amplitude integrated electro-encephalogram, LR: Likelihood ratio, CI: Confidence Interval, LOC: Level of consciousness.
HIE: Hypoxic ischaemic encephalopathy.
^a: When zero count cells are present, LR is estimated using a substitution formula: 0.5 is added to all cell frequencies before calculation.

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