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Table 1 Study population and database characteristics

From: Population-based analysis of non-steroidal anti-inflammatory drug use among children in four European countries in the SOS project: what size of data platforms and which study designs do we need to assess safety issues?

       Pediatric source population
(Age 0 to 18 years)
Database Country Type of database Diagnoses captured with: Drugs captured with: Study period Number of persons Person-years of observation Number of NSAID users
GePaRD Germany Claims database ICD-10-GM ATC 2005 - 2008 2,992,087 7,056,919 925,667
THIN United Kingdom General practice database READ BNF/Multilex/ATC 1999 – 2008 1,261,668 5,198,351 227,927
IPCI Netherlands General practice database ICPC and free text ATC 1999 – 2011 250,296 618,479 12,002
PHARMO Netherlands Record linkage system ICD-9-CM ATC 1999 – 2008 594,800 2,914,576 82,233
OSSIFF Italy National Health Services registry (claims) ICD-9-CM ATC 2000 – 2008 675,197 3,671,014 22,760
SISR Italy National Health Services registry (claims) ICD-9-CM ATC 2002 – 2009 1,744,525 9,111,635 34,308
Pedianet* Italy General practice pediatric database ICD-9-CM and free text ATC 2000 – 2010 221,115 1,064,867 34,575
Total       7,739,688 29,635,841 1,339,472
  1. *Pedianet only includes children up to the age of 14 years.
  2. ICD-10-GM: International Classification of Diseases, 10th Revision German Modified; ICD-9-CM: International Classification of Diseases, 9th Revision Clinically Modified; ICPC: International Classification for Primary Care; ATC: Anatomical Therapeutic Chemical classification; BNF: British National Formulary.